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  4. Recombinant Mouse Cyclin-dependent kinases regulatory subunit 1 (Cks1b)

Recombinant Mouse Cyclin-dependent kinases regulatory subunit 1 (Cks1b)

  • 中文名稱：
    Recombinant Mouse Cyclin-dependent kinases regulatory subunit 1(Cks1b)
  • 貨號：
    CSB-YP005464MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cyclin-dependent kinases regulatory subunit 1(Cks1b)
  • 貨號：
    CSB-EP005464MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cyclin-dependent kinases regulatory subunit 1(Cks1b)
  • 貨號：
    CSB-EP005464MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Cyclin-dependent kinases regulatory subunit 1(Cks1b)
  • 貨號：
    CSB-BP005464MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cyclin-dependent kinases regulatory subunit 1(Cks1b)
  • 貨號：
    CSB-MP005464MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Cks1b
  • Uniprot No.：
  • 別名：
    Cks1b; Cks1; Sid1334Cyclin-dependent kinases regulatory subunit 1; CKS-1; Sid 1334
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    2-79
  • 氨基酸序列
    SHKQIYYSD KYDDEEFEYR HVMLPKDIAK LVPKTHLMSE SEWRNLGVQQ SQGWVHYMIH EPEPHILLFR RPLPKKPKK
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
  • 基因功能參考文獻(xiàn)：
    1. Our results revealed that CKS1 is involved in normal glutamatergic synapse development and dendritic spine maturation in adult hippocampus through modulating p27 stability. PMID: 28365778
    2. Cks1 is critical for Bcr-Abl-induced cytokine-independent clonogenic activity. PMID: 25417705
    3. show that CKS2 counteracts CKS1 and stabilizes p27 PMID: 22898779
    4. Cks1 is overexpressed in various B cell malignancies, is required for tumor cell proliferation but is not sufficient to induce hematopoietic malignancies. PMID: 22624029
    5. establish p27(Kip1)-independent functions of Cks1 in regulating the G(1)-S transition PMID: 22508990
    6. Collectively, these findings suggest that Cks1 targets, in addition to p27(Kip1), are critical for Myc-driven proliferation and tumorigenesis. PMID: 20197382
    7. FGFR kinase regulates the cell cycle through phosphorylation-dependent release of Cks1 from FGFR substrate 2 PMID: 15513912
    8. Elevated expression of Cks1 may contribute to prostate tumorigenesis by promoting proliferation, anchorage-independent growth and migration of the cells, and elevated expression of Cks2 by protecting cells from undergoing programmed cell death. PMID: 18498131
    9. Data show that cyclin-dependent kinase-associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells. PMID: 18625720

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  • 蛋白家族：
    CKS family
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:54124

    STRING: 10090.ENSMUSP00000029679

    UniGene: Mm.3049



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