Recombinant Mouse Collectin-11 (Colec11)

中文名稱：

Recombinant Mouse Collectin-11(Colec11)
貨號：

CSB-YP663567MO
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Collectin-11(Colec11)
貨號：

CSB-EP663567MO
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Collectin-11(Colec11)
貨號：

CSB-EP663567MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Collectin-11(Colec11)
貨號：

CSB-BP663567MO
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Collectin-11(Colec11)
貨號：

CSB-MP663567MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Colec11
Uniprot No.：

Q3SXB8
別名：

Colec11Collectin-11; Collectin kidney protein 1; CL-K1
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

27-272
氨基酸序列

QQTT EDACSVQILV PGLKGDAGEK GDKGAPGRPG RVGPTGEKGD MGDKGQKGTV GRHGKIGPIG AKGEKGDSGD IGPPGPSGEP GIPCECSQLR KAIGEMDNQV TQLTTELKFI KNAVAGLRET ESKIYLLVKE EKRYADAQLS CQARGGTLSM PKDEAANGLM ASYLAQAGLA RVFIGINDLE KEGAFVYSDR SPMQTFNKWR SGEPNNAYDE EDCVEMVASG GWNDVACHIT MYFMCEFDKE NL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding. Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis.
基因功能參考文獻：
1. this study demonstrates the role of CL-11 and the molecular mechanisms involved in modulating retinal pigment epithelial cell phagocytosis and cytokine production PMID: 28772263
2. CL-K1-/- mice revealed decreased phagocytosis of Streptococcus pneumoniae PMID: 28068663
3. intrarenal expression of COLEC11 rapidly increases in the postischemic period and colocalizes with complement deposited along the basolateral surface of the proximal renal tubule in association with L-fucose, the potential binding ligand for COLEC11. PMID: 27088797
4. identify collectin CL-LK as a novel soluble C-type lectin able to bind M. tuberculosis, and characterize mycobacterial mannose-capped lipoarabinomannan as a primary ligand for CL-LK PMID: 26173080
5. This profile of CL-K1 expression is unique among the collectins. [CL-K1] PMID: 18040075
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亞細胞定位：

Secreted.
蛋白家族：

COLEC10/COLEC11 family
組織特異性：

Highly expressed in embryonic murine craniofacial cartilage, heart, bronchi, kidney and vertebral bodies.
數據庫鏈接：

KEGG: mmu:71693

STRING: 10090.ENSMUSP00000049285

UniGene: Mm.30724