Recombinant Mouse Collagen and calcium-binding EGF domain-containing protein 1 (Ccbe1)

中文名稱：

Recombinant Mouse Collagen and calcium-binding EGF domain-containing protein 1(Ccbe1)
貨號：

CSB-YP662138MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Collagen and calcium-binding EGF domain-containing protein 1(Ccbe1)
貨號：

CSB-EP662138MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Collagen and calcium-binding EGF domain-containing protein 1(Ccbe1)
貨號：

CSB-EP662138MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Collagen and calcium-binding EGF domain-containing protein 1(Ccbe1)
貨號：

CSB-BP662138MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Collagen and calcium-binding EGF domain-containing protein 1(Ccbe1)
貨號：

CSB-MP662138MO
規(guī)格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ccbe1
Uniprot No.：

Q3MI99
別名：

Ccbe1; Kiaa1983Collagen and calcium-binding EGF domain-containing protein 1; Full of fluid protein homolog
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區(qū)域：

36-408
氨基酸序列

YREEP EDRDREVCSE NKITTTKYPC LKSSGELTTC FRKKCCKGYK FVLGQCIPED YDICAQAPCE QQCTDNFGRV LCTCYPGYRY DRERHQKRER PYCLDIDECA TSNTTLCAHI CINTMGSYHC ECREGYILED DGRTCTRGDK YPNDTGHEEK SENEVKAGTC CATCKEFSQM KQTVLQLKQK MALLPNNAAE LGKYVNGDKV LASNAYLPGP PGLPGGQGPP GSPGPKGSPG FPGMPGPPGQ PGPRGSMGPM GPSPDLSHIK QGRRGPVGPP GAPGRHGSKG ERGAPGPPGS PGPPGSFDFL LLVLADIRND IAELQEKVFG HRTHSSAEDF PLPQEFSSYP ETLDFGSGDD YSRRTEARDP EAPRNFYP
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis.
基因功能參考文獻：
1. CCBE1 is essential for coronary vessel formation, independent of their embryonic origin, and is also necessary for peritruncal vessel growth and proper CA stem patterning. PMID: 30204931
2. Collagen domains of CCBE1 are crucial for the activation of VEGFC in vitro and in vivo. The EGF domains of CCBE1 are dispensable for regulation of VEGFC processing in vitro, however, they are necessary for full lymphangiogenic activity of CCBE1 in vivo. PMID: 25814692
3. CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation. PMID: 24552833
4. Ccbe1 has an essential role in lymphangiogenesis [review] PMID: 24276893
5. The secreted lymphangiogenic protein CCBE1 is essential for fetal but not postnatal erythropoiesis. PMID: 23426945
6. Ccbe1 expression marks the cardiac and lymphatic progenitor lineages during early stages of mouse development PMID: 22252499
7. Phenotypic analysis of murine Ccbe1 mutant embryos show a complete lack of definitive lymphatic structures, even though lymphatic endothelial cells are specified within the cardinal vein PMID: 21778431
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亞細胞定位：

Secreted.
蛋白家族：

CCBE1 family
數據庫鏈接：

KEGG: mmu:320924

STRING: 10090.ENSMUSP00000052011

UniGene: Mm.442049