Recombinant Mouse CUGBP Elav-like family member 2 (Celf2)

中文名稱：

Recombinant Mouse CUGBP Elav-like family member 2(Celf2)
貨號：

CSB-YP897450MO
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse CUGBP Elav-like family member 2(Celf2)
貨號：

CSB-EP897450MO
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse CUGBP Elav-like family member 2(Celf2)
貨號：

CSB-EP897450MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse CUGBP Elav-like family member 2(Celf2)
貨號：

CSB-BP897450MO
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse CUGBP Elav-like family member 2(Celf2)
貨號：

CSB-MP897450MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Celf2
Uniprot No.：

Q9Z0H4
別名：

Celf2; Cugbp2; Napor; CUGBP Elav-like family member 2; CELF-2; Bruno-like protein 3; CUG triplet repeat RNA-binding protein 2; CUG-BP2; CUG-BP- and ETR-3-like factor 2; ELAV-type RNA-binding protein 3; ETR-3; mETR-3; Neuroblastoma apoptosis-related RNA-binding protein; mNapor; RNA-binding protein BRUNOL-3
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-508
氨基酸序列

MRCPKSAVTM RNEELLLSNG TANKMNGALD HSDQPDPDAI KMFVGQIPRS WSEKELKELF EPYGAVYQIN VLRDRSQNPP QSKGCCFVTF YTRKAALEAQ NALHNIKTLP GMHHPIQMKP ADSEKSNAVE DRKLFIGMVS KKCNENDIRV MFSPFGQIEE CRILRGPDGL SRGCAFVTFS TRAMAQNAIK AMHQSQTMEG CSSPIVVKFA DTQKDKEQRR LQQQLAQQMQ QLNTATWGNL TGLGGLTPQY LALLQQATSS SNLGAFSGIQ QMAGMNALQL QNLATLAAAA AAAQTSATST NANPLSSTSS ALGALTSPVA ASTPNSTAGA AMNSLTSLGT LQGLAGATVG LNNINALAGM AALNGGLGAT GLTNGTAGTM DALTQAYSGI QQYAAAALPT LYSQSLLQQQ SAAGSQKEGP EGANLFIYHL PQEFGDQDIL QMFMPFGNVI SAKVFIDKQT NLSKCFGFVS YDNPVSAQAA IQAMNGFQIG MKRLKVQLKR SKNDSKPY
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury. Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA. Binds to an intronic RNA element responsible for the silencing of exon 21 splicing. Binds to (CUG)n repeats. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA.
基因功能參考文獻：
1. Napor-3 suppression by ethanol during mid and late stage fetal brain converts natural physiological event apoptosis into a pathological process. PMID: 19114963
2. Colonic MSCs expressed high Ptgs2 levels as a consequence of mRNA stabilization downstream of Fgf9. This stabilization was mediated partially through a mechanism involving endogenous CUG-binding protein 2. PMID: 20018844
3. A renmarkable decrease in CUG-binding protein-2 (Cugbp2) expression is seen in the pyramidal cells of the hippocampus following neuronal degeneration. PMID: 19559013
4. NAPOR may be one of a group of closely related proteins involved in splicing regulation within the brain. PMID: 12022233
5. Data demonstrate that cells expressing CUGBP2 variant 1 undergo apoptosis during mitosis, suggesting mitotic catastrophe. PMID: 18258790
6. CUGBP2 interacts with functionally significant RNA motifs surrounding the branch sites upstream of exon 6 of the CUGBP2 transcript itself. PMID: 19680430
顯示更多

收起更多
亞細胞定位：

Nucleus. Cytoplasm.
蛋白家族：

CELF/BRUNOL family
組織特異性：

Expressed in tongue, spleen and brain (at protein level). Expressed in liver, thigh, stomach, lung and heart to very low levels (at protein level). Expressed in heart, brain, lung and muscle.
數據庫鏈接：

KEGG: mmu:14007

STRING: 10090.ENSMUSP00000110574

UniGene: Mm.398543