Recombinant Mouse Bardet-Biedl syndrome 5 protein homolog (Bbs5)

中文名稱：

Recombinant Mouse Bardet-Biedl syndrome 5 protein homolog(Bbs5)
貨號：

CSB-YP875167MO
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Bardet-Biedl syndrome 5 protein homolog(Bbs5)
貨號：

CSB-EP875167MO
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Bardet-Biedl syndrome 5 protein homolog(Bbs5)
貨號：

CSB-EP875167MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Bardet-Biedl syndrome 5 protein homolog(Bbs5)
貨號：

CSB-BP875167MO
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Bardet-Biedl syndrome 5 protein homolog(Bbs5)
貨號：

CSB-MP875167MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Bbs5
Uniprot No.：

Q9CZQ9
別名：

Bbs5Bardet-Biedl syndrome 5 protein homolog
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-341
氨基酸序列

MSVLDVLWED RDVRFDVSSQ QMKTRPGEVL IDCLDSIEDT KGNNGDRGRL LVTNLRIIWH SLALPRVNLS IGYNCILNIT TRTANSKLRG QTEALYILTK CNTTRFEFIF TNLVPGSPRL FTSVIAVHRA YETSKMYRDF KLRSAVIQNK QLRLLPQEHV YDKINGVWNL SSDQGNLGTF FITNVRIVWH ANMNDSFNVS IPYLQIRSIK IRDSKFGLAL VIESSQQSGG YVLGFKIDPV EKLQESVKEI NSLHKVYSAS PIFGVNYEME EKPQPLEALT VEQIQDDVEI DSDDHTDAFV AYFADGNKQQ DREPVFSEEL GLAIEKLKDG FTLQGLWEVM S
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
基因功能參考文獻：
1. Findings suggest a role for Bardet-Biedl syndrome 5 (BBS5) in regulating light-dependent translocation of arrestin1 (Arr1). PMID: 23817741
亞細胞定位：

Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to basal bodies.
蛋白家族：

BBS5 family
數據庫鏈接：

KEGG: mmu:72569

STRING: 10090.ENSMUSP00000074494

UniGene: Mm.252136