Recombinant Mouse BRISC and BRCA1-A complex member 1 (Babam1)

中文名稱：

Recombinant Mouse BRISC and BRCA1-A complex member 1(Babam1)
貨號：

CSB-YP661041MO
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse BRISC and BRCA1-A complex member 1(Babam1)
貨號：

CSB-EP661041MO
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse BRISC and BRCA1-A complex member 1(Babam1)
貨號：

CSB-EP661041MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse BRISC and BRCA1-A complex member 1(Babam1)
貨號：

CSB-BP661041MO
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse BRISC and BRCA1-A complex member 1(Babam1)
貨號：

CSB-MP661041MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Babam1
Uniprot No.：

Q3UI43
別名：

Babam1; Merit40; Nba1BRISC and BRCA1-A complex member 1; Mediator of RAP80 interactions and targeting subunit of 40 kDa; New component of the BRCA1-A complex
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-333
氨基酸序列

MEVAEANSPT EEEEEEEEEG EETISEPRPH TRSNPEGAED RALGAQASVG SRSEGEGEAA TADGGAASVP GAGPKPWQVP ASASEVQIRT PRVNCPEKVI ICLDLSEEMS VPKLESFNGS RTNALNVSQK MVEMFVRTKH KIDKSHEFAL VVVNDDSAWL SGLTSDPREL CSCLYDLETA SCSTFNLEGL FSLIQQKTEL PVTENVQTIP PPYVVRTILV YSRPPCQPQF SLTEPMKKMF QCPYFFFDIV YIHNGTEEKE EDMSWKDMFA FMGSLDTKGA SYKYEVALAG PALELHNCMA KLLAHPLQRP CQTHASYSLL EEDEEAGEEE ATV
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination.
基因功能參考文獻：
1. Merit40 mutation exacerbated ICL-induced chromosome instability in the context of concomitant Brca2 deficiency but not in conjunction with Fancd2 mutation. PMID: 26338419
2. MERIT40(-/-) hematopoietic stem cells are more resistant to cytoablative stress, and exhibit superior repopulating ability and self-renewal upon serial transplantation. PMID: 25636339
亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

BABAM1 family
數據庫鏈接：

KEGG: mmu:68251

STRING: 10090.ENSMUSP00000002473

UniGene: Mm.21749