Recombinant Mouse Aryl hydrocarbon receptor repressor (Ahrr)

中文名稱：

Recombinant Mouse Aryl hydrocarbon receptor repressor(Ahrr)
貨號：

CSB-YP664924MO
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Aryl hydrocarbon receptor repressor(Ahrr)
貨號：

CSB-EP664924MO
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Aryl hydrocarbon receptor repressor(Ahrr)
貨號：

CSB-EP664924MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Aryl hydrocarbon receptor repressor(Ahrr)
貨號：

CSB-BP664924MO
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Aryl hydrocarbon receptor repressor(Ahrr)
貨號：

CSB-MP664924MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ahrr
Uniprot No.：

Q3U1U7
別名：

Ahrr; Kiaa1234Aryl hydrocarbon receptor repressor; AhR repressor; AhRR
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-701
氨基酸序列

MMIPSGECTY AGRKRRKPIQ KRRLTMGAEK SNPSKRHRDR LNTELDHLAS LLPFSPDIIS KLDKLSVLRL SVSYLRVKSF FQALQETCVW SAPALSPEEH SYRGFPVQEG RLLLESLNGF ALVVSAEGMI FYASATIVDY LGFHQTDVMH QNIYDYIHVD DRQDFCRQLH WAMDPPQVVF GQSPHADTDN TVLGKLLRAQ EGGKGLPSEY SAFLTRCFIC RVRCLLDSTS GFLTMQFQGK LKFLFGQKKK TPSGTALPPR LSLFCIVAPV LPSVTEMKMK STFLKAKHRA DIVVTMDSRA KAVTSLCESE LHPKLNYLAG KSNGENGISL FRGQTDRSHW ARALARSSCL CLRGGPDLLD PKGTSGDREE EDQKHILRRS PGAWGQREMH KYSYGLETPV HLRHLNWSTE QRSQESTTKL TRQPSKNEPS TCLVPHGSCV PYPGSQGMLS ASNMASFRDS LDHPTGAYCS QMNRPLSDIH QGQVDPSTCH ISQGSLGSRI PLTGMQRFTA RGFSTEDAKL PSLPVTIGTP CNPVLSLDVP IKMENESGSQ DIVEASTTSC LWLGTSDMAR GHLVGFPARM HLKTEPDYRQ QACTPHLGHG MLGTNPYSRD TVGSCREHAP LYSAHCTCLD PEPPHHLFMC SHSESQHPSL DQDCRAPIVK REPLDSPSWA APGQVTVPRM FPKSASKTVI PSKGSDGIFL P
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
基因功能參考文獻：
1. These findings highlight the physiologic importance of cell-type specific balancing of AhR/AhRR expression in response to microbial, nutritional and other environmental stimuli. Specifically, AhRR contributes to the maintenance of colonic intraepithelial lymphocytes and prevents excessive IL-1beta production and Th17/Tc17 differentiation. In contrast, the AhRR enhances IFN-gamma-production by effector T cells in the in... PMID: 27184933
2. Suggest AHRR mediates dioxin inhibition of lactation by blocking transcription of beta-casein. PMID: 25265996
3. Immortalized TiPARP(-/-) mouse embryonic fibroblasts (MEFs) and AHRR(-/-) MEFs exhibited enhanced AHR transactivation. PMID: 24806346
4. AhRR mRNA expression pattern in untreated C57BL/6 mice varies across tissues with high levels in hearts and brains PMID: 16205913
亞細胞定位：

Cytoplasm. Nucleus. Note=Predominantly in the nuclear compartment. First cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment.
數據庫鏈接：

KEGG: mmu:11624

STRING: 10090.ENSMUSP00000022059

UniGene: Mm.290446