Recombinant Mouse Ankyrin repeat and SOCS box protein 4 (Asb4)

中文名稱：

Recombinant Mouse Ankyrin repeat and SOCS box protein 4(Asb4)
貨號(hào)：

CSB-YP896256MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Ankyrin repeat and SOCS box protein 4(Asb4)
貨號(hào)：

CSB-EP896256MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Ankyrin repeat and SOCS box protein 4(Asb4)
貨號(hào)：

CSB-EP896256MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Ankyrin repeat and SOCS box protein 4(Asb4)
貨號(hào)：

CSB-BP896256MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Ankyrin repeat and SOCS box protein 4(Asb4)
貨號(hào)：

CSB-MP896256MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Asb4
Uniprot No.：

Q9WV71
別名：

Asb4Ankyrin repeat and SOCS box protein 4; ASB-4
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

full length protein
表達(dá)區(qū)域：

1-426
氨基酸序列

MDGITAPISK AGAAKLVKKD FLEALKTNDF GKLKAILIER QIDVDTVFEV EDENMILASY KQGYWLPSYK LKSSWATGLH LSVLLGHVEC LMVLLDHNAT INCRPNGKTP LHVACEIANL ECVKILCDRG AKLNCYSLSG HTALHFCTTP SSILCAKQLV LRGANVNMKT NNQDEETPLH TAAHFGLSEL VAFYVENGAI VDSMNAHMET PLAIATYWAL RFKEQEYSRE HHLICRTLLD NNAEVNARDD DFKSPLHKAA WNCDHVLMHM MLEAGAEANL MDINGCAAIQ YVLKVTSVRP AAQPEICYQL LLNHGAARIY PPQFHKVIQA CHSCPKAIEV VVNAYEHIRW NIKWRRAIPD DDLEKHWDFY HSLFKVCCNT PRTLMHLSRC AIRKALHNRC HKAIPMLSLP LPLKKYLLLE PEGIIY
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism.
基因功能參考文獻(xiàn)：
1. Expression of imprinted gene Asb4 was unregulated in haploid androgenetic/gynogenetic blastocysts. PMID: 24387305
2. In functional endothelial co-culture assays, JAR cells ectopically expressing ASB4 increased endothelial cell turnover and stabilized endothelial tube formation, both of which are hallmarks of vascular differentiation within the placenta. PMID: 24586788
3. The interaction of Asb-4 with IRS4 in cell lines mediates the degradation of IRS4 and decreases insulin signaling. PMID: 21955513
4. Tumor necrosis factor alpha upregulates ankyrin repeat and suppressor of cytokine signalling box protein 4 expression. PMID: 21506136
5. Asb-4 is a key regulatory protein in the central nervous system, involved in the control of feeding behavior and metabolic rate. PMID: 19934378
6. Asb4 has been identified as an imprinted gene by high-throughput screening using RIKEN cDNA microarray. PMID: 11820791
7. Based on its differential expression, neuroanatomical distribution and colocalisation, we hypothesise that rat Asb-4 is a gene involved in energy homeostasis. PMID: 15929745
8. These results suggest that ASB-4 plays pivotal roles in mammalian testis development and spermatogenesis. PMID: 18414003
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蛋白家族：

Ankyrin SOCS box (ASB) family
組織特異性：

Highest expression detected in testis, with some expression detected in ovary and heart. Not detected in lung, kidney, liver, spleen and bone marrow.
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:65255

STRING: 10090.ENSMUSP00000040331

UniGene: Mm.51340