Recombinant Mouse ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial (Clpx)

中文名稱：

Recombinant Mouse ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial(Clpx)
貨號(hào)：

CSB-YP872829MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial(Clpx)
貨號(hào)：

CSB-EP872829MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial(Clpx)
貨號(hào)：

CSB-EP872829MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial(Clpx)
貨號(hào)：

CSB-BP872829MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial(Clpx)
貨號(hào)：

CSB-MP872829MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Clpx
Uniprot No.：

Q9JHS4
別名：

ClpxATP-dependent Clp protease ATP-binding subunit clpX-like; mitochondrial
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

Full Length of Mature Protein
表達(dá)區(qū)域：

57-634
氨基酸序列

TFSE TPAYFASKDG ANKDGSGDGN KKSVTEGSSK KSGSGNSGKG GNQLRCPKCG DLCTHVETFV SSTRFVKCEK CHHFFVVLSE ADSKKSIIKE PESAAEAVKL AFQQKPPPPP KKIYNYLDKY VVGQSFAKKV LSVAVYNHYK RIYNNIPANL RQQAEAEKQT SLTPRELEIR RREDEYRFTK LLQIAGISPH GNALGASMQQ QVNQQMPQEK RGGEVLDSSQ DDIKLEKSNI LLLGPTGSGK TLLAQTLAKC LDVPFAICDC TTLTQAGYVG EDIESVIAKL LQDANYNVEK AQQGIVFLDE VDKIGSVPGI HQLRDVGGEG VQQGLLKLLE GTIVNVPEKN SRKLRGETVQ VDTTNVLFVA SGAFNGLDRI ISRRKNEKYL GFGTPSNLGK GRRAAAAADL ANRSGESNTH QDIEEKDRLL RHVEARDLIE FGMIPEFVGR LPVVVPLHSL DEKTLVQILT EPRNAVIPQY QALFSMDKCE LNVTEDALKA IARLALERKT GARGLRSIME KLLLEPMFEV PNSDIVCVEV DKEVVEGKKE PGYIRAPSKE SSEEEYDSGV EEDGWPRQAD AANS
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex. Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure. ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. Important for efficient erythropoiesis through upregulation of heme biosynthesis.
基因功能參考文獻(xiàn)：
1. results illustrate that ClpX overexpression is a good and simple model to study the underlying mechanisms of the UPRmt in mammalian cells. PMID: 26142927
2. Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors. PMID: 23851121
亞細(xì)胞定位：

Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid.
蛋白家族：

ClpX chaperone family
組織特異性：

Detected in liver (at protein level).
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:270166

STRING: 10090.ENSMUSP00000015501

UniGene: Mm.30088