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  4. Recombinant Human cytomegalovirus Envelope glycoprotein B (gB), partial

Recombinant Human cytomegalovirus Envelope glycoprotein B (gB), partial

  • 中文名稱：
    Recombinant Human cytomegalovirus Envelope glycoprotein B(gB) ,partial
  • 貨號：
    CSB-YP518800HWW
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human cytomegalovirus Envelope glycoprotein B(gB) ,partial
  • 貨號：
    CSB-EP518800HWW
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human cytomegalovirus Envelope glycoprotein B(gB) ,partial
  • 貨號：
    CSB-EP518800HWW-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human cytomegalovirus Envelope glycoprotein B(gB) ,partial
  • 貨號：
    CSB-BP518800HWW
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human cytomegalovirus Envelope glycoprotein B(gB) ,partial
  • 貨號：
    CSB-MP518800HWW
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    gB
  • Uniprot No.：
  • 別名：
    gB; UL55; Envelope glycoprotein B; gB
  • 種屬：
    Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.
  • 基因功能參考文獻：
    1. Data suggest that, unique among herpesviral gB proteins, the human cytomegalovirus fusion factor gB/UL55 has a Cys residue in the C-terminal region that is palmitoylated and mediates self-association of purified gB/UL55. PMID: 26694613
    2. Taken together, these data indicate that the YNND epitope of cytomegalovirus glycoprotein B (gB) represents an important target for anti-gB antibody responses as well as for anti-antigenic domain 5 virus-neutralizing antibodies PMID: 25320309
    3. These data support the hypothesis that human cytomegalovirus gH/gL binds cellular receptors before triggering gB, which acts as the fusion protein. PMID: 23736286
    4. A tyrosine (Y) at position 364 and a lysine (K) at position 379 (the YK epitope), which are immediate neighbors on the AD-4 surface, were found to be essential for binding of the human MAbs. PMID: 23740990
  • 亞細胞定位：
    Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Herpesviridae glycoprotein B family
  • 數據庫鏈接：

    KEGG: vg:3077424



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