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  4. Recombinant Human Serpin A12 (SERPINA12)

Recombinant Human Serpin A12 (SERPINA12)

  • 中文名稱：
    人SERPINA12重組蛋白
  • 貨號：
    CSB-YP812878HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SERPINA12重組蛋白
  • 貨號：
    CSB-EP812878HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SERPINA12重組蛋白
  • 貨號：
    CSB-EP812878HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SERPINA12重組蛋白
  • 貨號：
    CSB-BP812878HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SERPINA12重組蛋白
  • 貨號：
    CSB-MP812878HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SERPINA12
  • Uniprot No.：
  • 別名：
    ENSG00000165953; OL 64; OL-64; OL64; Serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 12; Serpin A12; Serpin A12 precursor; Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 12; Serpina12; SPA12_HUMAN; Vaspin; Visceral adipose specific serpin; Visceral adipose tissue derived serine protease inhibitor; Visceral adipose tissue-derived serine protease inhibitor; Visceral adipose-specific serpin
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    21-414
  • 氨基酸序列
    LKPSFSPRNY KALSEVQGWK QRMAAKELAR QNMDLGFKLL KKLAFYNPGR NIFLSPLSIS TAFSMLCLGA QDSTLDEIKQ GFNFRKMPEK DLHEGFHYII HELTQKTQDL KLSIGNTLFI DQRLQPQRKF LEDAKNFYSA ETILTNFQNL EMAQKQINDF ISQKTHGKIN NLIENIDPGT VMLLANYIFF RARWKHEFDP NVTKEEDFFL EKNSSVKVPM MFRSGIYQVG YDDKLSCTIL EIPYQKNITA IFILPDEGKL KHLEKGLQVD TFSRWKTLLS RRVVDVSVPR LHMTGTFDLK KTLSYIGVSK IFEEHGDLTK IAPHRSLKVG EAVHKAELKM DERGTEGAAG TGAQTLPMET PLVVKIDKPY LLLIYSEKIP SVLFLGKIVN PIGK
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues.
  • 基因功能參考文獻：
    1. Elevated levels of vaspin were associated with 1.7 times increased cardiovascular disease risk. PMID: 29673927
    2. vaspin rs2236242 polymorphism is not associated with metabolic syndrome in Egyptian women PMID: 27966294
    3. vaspin decreased miR-33a levels, which in turn increased ABCA1 expression and cholesteorl efflux. PMID: 29653102
    4. High vaspin expression is associated with osteoporosis and arterial stiffness. PMID: 28646476
    5. Serum vaspin concentrations were significantly higher in the type-2 diabetes mellitus (T2DM) group than in the T2DM + macrovascular complications group. PMID: 29065866
    6. Serum vaspin level may be a useful marker for the prediction of ovulation induction success in treatment with clomiphene citrate PMID: 28826039
    7. vaspin can play a role as a new marker in the diagnosis, severity assessment, and prognosis of subarachnoid hemorrhage PMID: 25720423
    8. Suggest vaspin could be involved in the pathophysiology of cirrhosis, but is not a good indicator of its origin or severity and does not impact the thrombotic activity of platelets. PMID: 28465646
    9. Vaspin may play an important compensatory role in obesity and insulin resistance in elderly people. PMID: 28553648
    10. Studied the effects of vaspin on lipopolysaccharide (LPS)induced acute respiratory distress syndrome (ARDS) in vivo and in vitro, and further explored the molecular basis and potential mechanisms underlying these effects. It was demonstrated that vaspin protects against LPSinduced ARDS through reversing EC barrier dysfunction via the suppression of inflammation, apoptosis and ROS generation in pulmonary ECs. PMID: 29039444
    11. Serum vaspin cannot be used as an independent marker for the presence of coronary artery disease in the general population. PMID: 28482816
    12. Vaspin is modified at all 3 predicted asparagine glycosylation sites near the reactive center loop. Biochemical data demonstrate that glycosylation does not hinder inhibition of the target protease kallikrein 7. Although binding affinity to heparin is slightly decreased, the protease inhibition reaction is still significantly accelerated in the presence of heparin. Glycosylation did not affect thermal stability. PMID: 28668641
    13. Vaspin was associated with a reduced risk of insulin resistance independently of BMI and pubertal stage and the association was influenced by body fat and physical activity in these adolescents. PMID: 27513492
    14. Study provides evidence that serum vaspin level could be regarded as the predictor for improvement of fatty liver and metabolic disturbance after laparoscopic vertical banded gastroplasty surgery in patients with severe obesity. PMID: 28746192
    15. The minor A allele of vaspin rs2236242 polymorphism plays a protective role against obesity and diabetes among women in Upper Egypt. The serum vaspin concentration was lower in minor protective allele carriers. PMID: 28479386
    16. In COPD, the meta-analysis of % predicted FEV1 in cases, the strongest association was shown for a splice variant in a previously unreported region, SERPINA12 (rs140198372, pmeta=5.72x10(-6)). PMID: 26917578
    17. Together, these data show that vaspin binds heparin with high affinity (KD = 21 +/- 2 nm) and that binding takes place at a basic patch on top of beta-sheet A and is different from other heparin-binding serpins. PMID: 27941022
    18. In patients with diabetic nephropathy (DNP), vaspin level does not change within the early stages of DNP; while it is higher in patients with decreased glomerular filtration rate, which may be related with increasing inflammation regardless of the stage of the kidney disease. PMID: 27216464
    19. vaspin could be visibly observed within the detectable concentrations of vaspin up to 5nM in both buffer and serum conditions. The sensitivity of this LFSA developed in this study was ranged from 0.137 to 25nM in buffer and from 0.105 to 25nM in spiked human serum, respectively. T PMID: 27916536
    20. Vaspin acts as a coordinator of the dynamic balance between bone formation and resorption processes; its action is affected by the cytokines of the RANKL/RANK/OPG system. Changes in the relationships between vaspin, bone markers, OPG, and RANKL might contribute to the development of osteoporosis in girls with anorexia nervosa. PMID: 28042653
    21. These findings suggest that vaspin and VAP-1 may play a role in the pathogenesis of psoriasis and can be used as markers of the disease; vaspin levels may reflect the severity of disease. PMID: 25279492
    22. Circulating vaspin levels were lower in nonalcoholic fatty liver disease. PMID: 27493109
    23. Circulating vaspin level is higher in women than in men in obese individuals. Vaspin had mediator effect between visceral fat and fat mass associations with resting metabolic rate in obese participants. PMID: 26058881
    24. High serum vaspin concentrations are associated with Obese type 2 diabetes mellitus. PMID: 26676943
    25. The minor allele of vaspin rs2236242 polymorphism plays a protective role against metabolic syndrome. PMID: 26472663
    26. High serum vaspin levels are associated with coronary artery disease in patients with type 2 diabetes. PMID: 26972957
    27. Vaspin might be a useful predictive biomarker in patients with AMI, and patients with low vaspin levels might have a high risk of a MACE. In addition, vaspin might have protective effects on the improvement of LVEF after AMI. PMID: 27322007
    28. High levels of serum vaspin is associated with obesity. PMID: 25470626
    29. Low vaspin blood levels in patients with prolactinomas. PMID: 26415032
    30. The development of clinically manifest arthritis after follow-up was associated with baseline serum vaspin levels. PMID: 26670468
    31. Mean vaspin and apelin levels were significantly lower in underweight children compared to controls PMID: 25915077
    32. serum visceral adipose tissue-derived serpin (vaspin) levels in patients with normal glucose regulation and recently diagnosed type 2 diabetes, was investigated. PMID: 26436376
    33. vaspin is a beneficial adipokine in obesity PMID: 25340725
    34. It is believed that vaspin could be regarded as a new link between obesity and related metabolic disorders, including glucose intolerance. PMID: 25945347
    35. during pregnancy, high vaspin concentration is significantly associated with insulin resistance in gestational diabetes mellitus PMID: 24929806
    36. structural and functional results reveal the mechanistic basis of how reactive centre loop sequence and exosite interaction in vaspin enable KLK7 recognition and regulate protease inhibition PMID: 26199422
    37. Serum vaspin levels showed no significant difference between the type 2 diabetics with renal insufficiency and without renal insufficiency. PMID: 25133192
    38. In the sepsis group, vaspin plasma concentration was about three-fold as high as in the median surgical control group. PMID: 25672472
    39. The expression of human vaspin (serpinA12) is positively correlated to body mass index and insulin sensitivity and increases glucose tolerance in vivo, suggesting a compensatory role in response to diminished insulin signaling in obesity. PMID: 24596079
    40. Higher vaspin levels are associated with obesity and type 2 diabetes mellitus. PMID: 25151227
    41. Vaspin levels have been shown to increase in acute ischemic stroke patients. The increased vaspin levels may vary depending on several factors in acute period of ischemic stroke. PMID: 23594688
    42. the correlations of visfatin/Nampt, vaspin, and RBP-4 with insulin resistance are tissue dependent. PMID: 24367155
    43. serum vaspin level was positively associated with c-IMT, independently of insulin resistance in a general population. PMID: 24529152
    44. vaspin is an adipokine that may have a role in metabolic syndrome in males PMID: 23992351
    45. A rare variant (rs61757459) in vaspin coding for the stop codon p.R211X is related to lower circulating vaspin (SERPINA12) concentrations. Structure analysis suggests misfolding and instability due to the absence of core structural domains. PMID: 23756768
    46. Vaspin rs2236242 gene polymorphism is associated with polycystic ovary syndrome risk. PMID: 24530312
    47. Serum vaspin concentrations are elevated in patients with ulcerative colitis. PMID: 24166663
    48. The plasma vaspin concentrations correlate with the severity of coronary artery disease. PMID: 23850850
    49. Variability in serum vaspin concentrations might be explained by its genetic variants. PMID: 22907691
    50. Low levels of circulating adiponectin and vaspin levels are associated with an increased risk of developing endometrial cancer. PMID: 23896633

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Serpin family
  • 組織特異性：
    Expressed in visceral adipose tissues.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18359

    OMIM: 617471

    KEGG: hsa:145264

    STRING: 9606.ENSP00000342109

    UniGene: Hs.99476



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