Recombinant Human Integrin alpha-10 (ITGA10), partial

貨號：

CSB-YP7154HU
規(guī)格：
來源：

Yeast
其他：

貨號：

CSB-EP7154HU
規(guī)格：
來源：

E.coli
其他：

貨號：

CSB-EP7154HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

貨號：

CSB-BP7154HU
規(guī)格：
來源：

Baculovirus
其他：

貨號：

CSB-MP7154HU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

ITGA10
Uniprot No.：

O75578
別名：

Integrin alpha-10; ITGA10; UNQ468/PRO827
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
表達區(qū)域：

Partial
氨基酸序列

/
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Integrin alpha-10/beta-1 is a receptor for collagen.
基因功能參考文獻：
1. Unique charge-dependent constraints on collagen recognition by integrin alpha10beta1 have been described. PMID: 27569273
2. CNS disease was associated with enhanced expression of cytoplasmic and membranous ITGA10 and nuclear PTEN (P < 0.0005, P = 0.002, P = 0.024, respectively). sCNSL presented decreased membranous CD44 and nuclear and cytoplasmic cadherin-11 expressions (P = 0.001, P = 0.006, P = 0.048, respectively). In PCNSL lactoferrin expression was upregulated (P < 0.0005). PMID: 28854563
3. Analyses of the functional regulatory domains of the integrin alpha 10 promoter suggest that AP-2epsilon and Ets-1 are involved in the transcriptional regulation of this gene in chondrocytes. PMID: 16684505
4. Mouse and human articular chondrocytes express extracellular splice variants of the alpha10 subunit PMID: 11731273
亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Integrin alpha chain family
組織特異性：

Widely expressed with highest expression in muscle and heart. Found in articular cartilage.
數(shù)據(jù)庫鏈接：

HGNC: 6135

OMIM: 604042

KEGG: hsa:8515

STRING: 9606.ENSP00000358310

UniGene: Hs.158237