Recombinant Human Hypoxia-inducible lipid droplet-associated protein (HILPDA), partial

中文名稱：

人HILPDA重組蛋白
貨號：

CSB-YP896910HU
規格：
來源：

Yeast
其他：

中文名稱：

人HILPDA重組蛋白
貨號：

CSB-EP896910HU
規格：
來源：

E.coli
其他：

中文名稱：

人HILPDA重組蛋白
貨號：

CSB-EP896910HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人HILPDA重組蛋白
貨號：

CSB-BP896910HU
規格：
來源：

Baculovirus
其他：

中文名稱：

人HILPDA重組蛋白
貨號：

CSB-MP896910HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

HILPDA
Uniprot No.：

Q9Y5L2
別名：

C7orf68; chromosome 7 open reading frame 68; HIG 2; HIG2; HIG2_HUMAN; HILPDA; hypoxia inducible gene 2; Hypoxia-inducible gene 2 protein; Hypoxia-inducible lipid droplet-associated protein; Hypoxia-inducible protein 2
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation.
基因功能參考文獻：
1. The expression of HIG2 was regulated by PVT1-miR-150 signaling, we transfected Hep G2 and BEL-7402 cell lines with PVT1 shRNA vectors or the combination of PVT1 shRNA vectors and miR-150 inhibitors. PMID: 30205391
2. Authors conclude that HIG2 is overexpressed in GBM and upregulated by hypoxia. PMID: 27329597
3. Study showed for the first time that HIG-2 and SOX11 mutually co-regulate each other, and that HIG-2 and SOX11 knock-down promote increased proliferation in a non-synergistic manner in primary mantle cell lymphoma cells. PMID: 26757780
4. data uncover HILPDA as a novel PPAR target that raises hepatic triglyceride storage via regulation of triglyceride secretion. PMID: 24876382
5. Data indicate that HIG2 (hypoxia-inducible gene 2) is a HIF-1alpha target in regulating cell survival during hypoxia. PMID: 23916472
6. there was no significant relationship between HIG2 expression and age, clinical stage and histology in either cervical cancer or endometrial cancer. PMID: 21614900
7. Data show that DBN1, SETMAR and HIG2 are direct transcriptional targets of the SOX11 protein. PMID: 21124928
8. HIG2 was up-regulated by hypoxia and HIF inducers in all cell types and mouse organs investigated and abundantly expressed in renal clear-cell carcinomas PMID: 20624928
9. may be used as a marker for early detection of ovarian clear cell adenocarcinoma PMID: 20134266
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亞細胞定位：

Lipid droplet. Secreted. Membrane; Single-pass membrane protein.
組織特異性：

Highly expressed in renal cell carcinoma cells but barely detectable in adjacent normal kidney tissue. Detected in some cervical and endometrial cancers. Expression also detected in fetal kidney with little or no expression observed in normal adult heart,
數據庫鏈接：

HGNC: 28859

OMIM: 617905

KEGG: hsa:29923

STRING: 9606.ENSP00000257696

UniGene: Hs.706124