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  4. Recombinant Human G patch domain-containing protein 3 (GPATCH3)

Recombinant Human G patch domain-containing protein 3 (GPATCH3)

  • 中文名稱：
    人GPATCH3重組蛋白
  • 貨號：
    CSB-YP822227HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人GPATCH3重組蛋白
  • 貨號：
    CSB-EP822227HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人GPATCH3重組蛋白
  • 貨號：
    CSB-EP822227HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人GPATCH3重組蛋白
  • 貨號：
    CSB-BP822227HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人GPATCH3重組蛋白
  • 貨號：
    CSB-MP822227HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    GPATCH3
  • Uniprot No.：
  • 別名：
    DKFZp686E0221; FLJ12455; G patch domain containing 3; G patch domain containing protein 3; G patch domain-containing protein 3; GPATC3; GPATCH3; GPTC3_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-525
  • 氨基酸序列
    MAVPGEAEEE ATVYLVVSGI PSVLRSAHLR SYFSQFREER GGGFLCFHYR HRPERAPPQA APNSALIPTD PAAEGQLLSQ TSATDVRPLS TRDSTPIQTR TCCCVISVRG LAQAQRLIRM YSGRRWLDSH GTWLPGRCLI RRLRLPTEAS GLGSFPFKTR KELQSWKAEN EAFTLADLKQ LPELNPPVLM PRGNVGTPLR VFLELIRACR LPPRIITQLQ LQFPKTGSSR RYGNVPFEYE DSETVEQEEL VYTAEGEEIP QGTYLADIPA SPCGEPEEEV GKEEEEESHS DEDDDRGEEW ERHEALHEDV TGQERTTEQL FEEEIELKWE KGGSGLVFYT DAQFWQEEEG DFDEQTADDW DVDMSVYYDR DGGDKDARDS VQMRLEQRLR DGQEDGSVIE RQVGTFERHT KGIGRKVMER QGWAEGQGLG CRCSGVPEAL DSDGQHPRCK RGLGYHGEKL QPFGQLKRPR RNGLGLISTI YDEPLPQDQT ESLLRRQPPT SMKFRTDMAF VRGSSCASDS PSLPD
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6.
  • 基因功能參考文獻：
    1. The results show the existence of high genetic heterogeneity in congenital glaucoma and the role of GPATCH3 in this disease. GPATCH3 is a new gene involved in ocular and craniofacial development. PMID: 28397860
  • 相關疾病：
    GPATCH3 variants may be involved in the pathogenesis of congenital glaucoma, an ocular disease characterized by marked increase of intraocular pressure at birth or early childhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor.
  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 組織特異性：
    Expressed in ocular tissues including retinal pigment epithelium, cornea, ciliary muscle and non-pigmented ciliary epithelium. Also expressed in optic nerve, cartilage, skin and lymph node.
  • 數據庫鏈接：

    HGNC: 25720

    OMIM: 617486

    KEGG: hsa:63906

    UniGene: Hs.10903



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