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  4. Recombinant Human Cytosolic 5'-nucleotidase 3 (NT5C3)

Recombinant Human Cytosolic 5'-nucleotidase 3 (NT5C3)

  • 中文名稱：
    人NT5C3A重組蛋白
  • 貨號：
    CSB-YP867122HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NT5C3A重組蛋白
  • 貨號：
    CSB-EP867122HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人NT5C3A重組蛋白
  • 貨號：
    CSB-EP867122HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NT5C3A重組蛋白
  • 貨號：
    CSB-BP867122HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NT5C3A重組蛋白
  • 貨號：
    CSB-MP867122HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    NT5C3A
  • Uniprot No.：
  • 別名：
    5NT3A_HUMAN; cN III ; cN-III; cNIII ; Cytosolic 5' nucleotidase 3; Cytosolic 5' nucleotidase III; Cytosolic 5''-nucleotidase 3; Cytosolic 5''-nucleotidase 3A; Cytosolic 5''-nucleotidase III; NT5C3; Nt5c3a; p36; P5''N-1; P5'N 1 ; P5'N1 ; P5N 1 ; P5N-1; P5N1 ; PN I ; PN-I; PNI ; PSN1 ; Pyrimidine 5' nucleotidase 1; Pyrimidine 5''-nucleotidase 1; UMPH ; UMPH1 ; Uridine 5' monophosphate hydrolase 1; Uridine 5''-monophosphate hydrolase 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-336
  • 氨基酸序列
    MRAPSMDRAA VARVGAVASA SVCALVAGVV LAQYIFTLKR KTGRKTKIIE MMPEFQKSSV RIKNPTRVEE IICGLIKGGA AKLQIITDFD MTLSRFSYKG KRCPTCHNII DNCKLVTDEC RKKLLQLKEK YYAIEVDPVL TVEEKYPYMV EWYTKSHGLL VQQALPKAKL KEIVAESDVM LKEGYENFFD KLQQHSIPVF IFSAGIGDVL EEVIRQAGVY HPNVKVVSNF MDFDETGVLK GFKGELIHVF NKHDGALRNT EYFNQLKDNS NIILLGDSQG DLRMADGVAN VEHILKIGYL NDRVDELLEK YMDSYDIVLV QDESLEVANS ILQKIL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate.
  • 基因功能參考文獻：
    1. Results from a study on gene expression variability markers in early-stage human embryos shows that NT5C3A is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    2. reduced expression of transketolase in pyrimidine 5'-nucleotidase deficient patients PMID: 27381654
    3. Pyrimidine-5'-nucleotidase Campinas is a new mutation (p.R56G) in the NT5C3 gene associated with pyrimidine-5'-nucleotidase type I deficiency. PMID: 25153905
    4. Results show that NT5C3 expression levels were significantly increased in patients with risk allele homozygote. PMID: 25000516
    5. New missense homozygous mutation (Q270Ter) in the pyrimidine 5' nucleotidase type I-related gene in two Indian families with hereditary non-spherocytic hemolytic anemia. PMID: 23139015
    6. All investigated mutant proteins display impaired catalytic properties and/or reduced thermostability, providing a rationale for the pathological effects of the mutations. PMID: 15604219
    7. These data highlight hUMP1/POMP role in proteasome assembly and further strengthen the prospect of genetic manipulation of the proteasomal system. PMID: 17349762
    8. 3 newly described missense mutations (c.187T>C, c.469G>C & c.740T>C) identified in patients with hemolytic anemia were characterized at protein level; the enzymes were altered in both thermal stability and catalytic efficiency PMID: 18499901
    9. genetic variation in NT5C3 might affect protein function and potentially influence drug response PMID: 19623099

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  • 相關疾病：
    P5N deficiency (P5ND)
  • 亞細胞定位：
    Cytoplasm.; [Isoform 2]: Endoplasmic reticulum.
  • 蛋白家族：
    Pyrimidine 5'-nucleotidase family
  • 組織特異性：
    Isoforms 1, 3 and 4 are expressed in reticulocytes. Isoform 4 is hardly detectable in bone marrow and fetal liver.
  • 數據庫鏈接：

    HGNC: 17820

    OMIM: 266120

    KEGG: hsa:51251

    STRING: 9606.ENSP00000242210

    UniGene: Hs.487933



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