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  4. Recombinant Human Cutaneous T-cell lymphoma-associated antigen 5 (CTAGE5), partial

Recombinant Human Cutaneous T-cell lymphoma-associated antigen 5 (CTAGE5), partial

  • 中文名稱：
    Recombinant Human Cutaneous T-cell lymphoma-associated antigen 5(CTAGE5) ,partial
  • 貨號(hào)：
    CSB-YP006131HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Cutaneous T-cell lymphoma-associated antigen 5(CTAGE5) ,partial
  • 貨號(hào)：
    CSB-EP006131HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Cutaneous T-cell lymphoma-associated antigen 5(CTAGE5) ,partial
  • 貨號(hào)：
    CSB-EP006131HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Cutaneous T-cell lymphoma-associated antigen 5(CTAGE5) ,partial
  • 貨號(hào)：
    CSB-BP006131HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Cutaneous T-cell lymphoma-associated antigen 5(CTAGE5) ,partial
  • 貨號(hào)：
    CSB-MP006131HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CTAGE5
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn)：
    1. TANGO1/CTAGE5 receptor serves as a polyvalent template for assembly of large COPII coats. PMID: 27551091
    2. In this study, we identified specific and critical residues in the Sec12-binding region of cTAGE5 (E75A K76A, K89A, and S97A) and confirmed that cTAGE5-mediated Sec12 accumulation at ER exit sites is required for collagen VII secretion. PMID: 27170179
    3. Data indicate that MIA2 represents a potential novel acute phase protein and MIA2 expression responds to liver damage in chronic liver diseases. PMID: 12586826
    4. The novel gene MIA2 acts as a tumour suppressor in hepatocellular carcinoma. PMID: 17881540
    5. population and bioinformatic analysis of MGEA6 P521A variation as a risk factor for Fahr's disease; genetic screen data show this mutation is very rare; bioinformatics analysis provided conflicting findings PMID: 20838928
    6. cTAGE5 forms a complex with TANGO1 (MIA3), a previously characterized cargo receptor for collagen VII PMID: 21525241
    7. HBx activates hepatoma cell growth and proliferation through repression of the potential tumor suppressor MIA2. PMID: 22120627
    8. 22 members of an Iranian family with basal ganglia calfication as well as 100 controls were genotyped for the C>G P521A variant of CTAGE5, but none were found. PMID: 23054591
    9. Findings suggest that the roles of MIA2 might be based on the variety of the integrins and the subtypes of mitogen-activated protein kinase in oral carcinoma. PMID: 23511560
    10. Sec12 recruitment to endoplasmic reticulum exit sites is organized by its direct interaction with cTAGE5, a previously characterized collagen cargo receptor component, which functions together with TANGO1 at endoplasmic reticulum exit sites. PMID: 25202031
    11. These findings define an interaction between the common MIA2(I141M) variant and the ER stress/UPR system and specify a subgroup of PDAC patients who are more likely to benefit from adjuvant chemotherapy. PMID: 25657029

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  • 相關(guān)疾病：
    Autoantibodies against CTAGE5 are present in several cancer types, including benign meningioma and cutaneous T-cell lymphoma (CTCL).
  • 蛋白家族：
    CTAGE family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7057

    OMIM: 602132

    STRING: 9606.ENSP00000280083

    UniGene: Hs.287694



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