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  4. Recombinant Human APC membrane recruitment protein 2 (FAM123A)

Recombinant Human APC membrane recruitment protein 2 (FAM123A)

  • 中文名稱：
    Recombinant Human APC membrane recruitment protein 2(FAM123A)
  • 貨號：
    CSB-YP850820HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human APC membrane recruitment protein 2(FAM123A)
  • 貨號：
    CSB-EP850820HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human APC membrane recruitment protein 2(FAM123A)
  • 貨號：
    CSB-EP850820HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human APC membrane recruitment protein 2(FAM123A)
  • 貨號：
    CSB-BP850820HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human APC membrane recruitment protein 2(FAM123A)
  • 貨號：
    CSB-MP850820HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    AMER2
  • Uniprot No.：
  • 別名：
    AMER2; FAM123AAPC membrane recruitment protein 2; Amer2; Protein FAM123A
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-671
  • 氨基酸序列
    METSRSRGGG GAVSERGGAG ASVGVCRRKA EAGAGTGTLA ADMDLHCDCA AETPAAEPPS GKINKAAFKL FKKRKSGGTM PSIFGVKNKG DGKSSGPTGL VRSRTHDGLA EVLVLESGRK EEPRGGGDSG GGGGGRPNPG PPRAAGPGGG SLASSSVAKS HSFFSLLKKN GRSENGKGEP VDASKAGGKQ KRGLRGLFSG MRWHRKDKRA KAEAAEGRAP GGGLILPGSL TASLECVKEE TPRAAREPEE PSQDAPRDPA GEPAGGEEVP APADRAPARS CREAEGLAHP GDTGARGEDA AGHRRAEPGP GEVRTAEDAS RTGAVPVKTV PLVDSEGGSG RAPAAPDPAS VDPPSDPSAD RICLMFSDVT SLKSFDSLTG CGDIIADQEE EAGPSCDKHV PGPGKPALSK KNPGVVAYQG GGEEMASPDE VDDTYLQEFW DMLSQTEEQG PEPQEGAAKV AAALETKVVP ETPKDTRCVE AAKDASSVKR RRLNRIPIEP HPKEEPKHPE KEQQEGVPNS DEGYWDSTTP GPEEDSSSSG KKAGIPRDSY SGDALYDLYA DPDGSPATLP GGKDNEETSS LSRLKPVSPG TITCPLRTPG SLLKDSKIPI SIKHLTNLPS SHPVVHQQPS RSEMPRTKIP VSKVLVRRVS NRGLAGTTIR ATACHDSAKK L
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex.
  • 基因功能參考文獻：
    1. FAM123A binds to microtubules and inhibits the guanine nucleotide exchange factor ARHGEF2 to decrease actomyosin contractility. PMID: 22949735
    2. the Amer2-EB1-APC complex regulates cell migration by altering microtubule stability. PMID: 22898821
    3. data characterize Amer2 for the first time as a negative regulator of Wnt signaling both in cell lines and in vivo and define Amer proteins as a novel family of Wnt pathway regulators. PMID: 22128170
  • 亞細胞定位：
    Cell membrane; Peripheral membrane protein. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2.
  • 蛋白家族：
    Amer family
  • 數據庫鏈接：

    HGNC: 26360

    OMIM: 614659

    KEGG: hsa:219287

    STRING: 9606.ENSP00000426528

    UniGene: Hs.528335



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