Recombinant Glycogen synthase kinase-3 (gsk-3)

中文名稱：

秀麗隱桿線蟲gsk-3重組蛋白
貨號：

CSB-YP886973CXY
規(guī)格：
來源：

Yeast
其他：

中文名稱：

秀麗隱桿線蟲gsk-3重組蛋白
貨號：

CSB-EP886973CXY
規(guī)格：
來源：

E.coli
其他：

中文名稱：

秀麗隱桿線蟲gsk-3重組蛋白
貨號：

CSB-EP886973CXY-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

秀麗隱桿線蟲gsk-3重組蛋白
貨號：

CSB-BP886973CXY
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

秀麗隱桿線蟲gsk-3重組蛋白
貨號：

CSB-MP886973CXY
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

gsk-3
Uniprot No.：

Q9U2Q9
別名：

gsk-3; sgg-1; Y18D10A.5Glycogen synthase kinase-3; EC 2.7.11.26
種屬：

Caenorhabditis elegans
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-362
氨基酸序列

MNKQLLSCSL KSGKQVTMVV ASVATDGVDQ QVEISYYDQK VIGNGSFGVV FLAKLSTTNE MVAIKKVLQD KRFKNRELQI MRKLNHPNIV KLKYFFYSSG EKKDELYLNL ILEYVPETVY RVARHYSKQR QQIPMIYVKL YMYQLLRSLA YIHSIGICHR DIKPQNLLID PESGVLKLCD FGSAKYLVRN EPNVSYICSR YYRAPELIFG ATNYTNSIDV WSAGTVMAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IQSMNPNYKE FKFPQIKAHP WNKVFRVHTP AEAIDLISKI IEYTPTSRPT PQAACQHAFF DELRNPDARL PSGRPLPTLE MDGPMGTGEV STTSGDVAGP SA
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting mesoderm development. Required for normal lifespan and LiCl-induced lifespan extension.
基因功能參考文獻(xiàn)：
1. In C. elegans germline stem cells, loss of gsk-3 results in reduced germline stem cell proliferation without changes in differentiation or responsiveness to GLP-1/Notch signaling. PMID: 29695611
2. Rearrangement of mitotic spindles requires the GSK-3 kinase. Apoptotic cell clearance and migration of the distal tip cell require the GSK-3 kinase. PMID: 20126385
3. (i) GSK-3 inhibits SKN-1 activity in the intestine, (ii) the phase II response integrates multiple regulatory signals, and (iii), by inhibiting this response, GSK-3 may influence redox conditions. PMID: 16251270
4. GSK3 converts OMA-1 and OMA-2 from being key regulators of oocyte maturation to key regulators of 1-cell embryo development PMID: 16289132
蛋白家族：

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, GSK-3 subfamily
數(shù)據(jù)庫鏈接：

KEGG: cel:CELE_Y18D10A.5

STRING: 6239.Y18D10A.5.2

UniGene: Cel.7399