Recombinant F-box/SPRY domain-containing protein 1 (fsn-1)

中文名稱：

秀麗隱桿線蟲fsn-1重組蛋白
貨號：

CSB-YP621106CXY
規格：
來源：

Yeast
其他：

中文名稱：

秀麗隱桿線蟲fsn-1重組蛋白
貨號：

CSB-EP621106CXY
規格：
來源：

E.coli
其他：

中文名稱：

秀麗隱桿線蟲fsn-1重組蛋白
貨號：

CSB-EP621106CXY-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

秀麗隱桿線蟲fsn-1重組蛋白
貨號：

CSB-BP621106CXY
規格：
來源：

Baculovirus
其他：

中文名稱：

秀麗隱桿線蟲fsn-1重組蛋白
貨號：

CSB-MP621106CXY
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

fsn-1
Uniprot No.：

Q18223
別名：

fsn-1; C26E6.5F-box/SPRY domain-containing protein 1; F-box synaptic protein 1
種屬：

Caenorhabditis elegans
蛋白長度：

full length protein
表達區域：

1-332
氨基酸序列

MAENDGETIV PDEQCNLTAS TPMKSSGLEQ VESPKERKTS MVECDDEGNP SSGTPDESPK QLTPHSIPPR RRRSPRRPEV SASRLPLKVL NQIFQYLPLK DLRSAMLTCH SWNNALSMED SDIWQYLLGK KLPEAAVSDP FLLAELGSAK KKLRAWYFAW NTSDISRNNY IRTNGFTVHR QPVAQSTDGV RGKRGISKGV HAFDITWDGP LGTVAVVGIA TKHAALHCVG YVALLGSDDQ SWGWNLVDNV LMHNGAQLGV YPKMNNPPKY EVGDKIRLII DCDTHVAYFE RNSEFLGIAF NHIPPLRLYP AVCAVYGNTE VTMVYVGSPQ MG
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf-2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM and ALM neurons.
基因功能參考文獻：
1. region of RPM-1 that is sufficient in binding to FSN-1 PMID: 25326385
2. FSN-1 may negatively regulate insulin/IGF signalling, in part, through EGL-3-dependent insulin-like ligand processing. PMID: 23665919
3. identification of FSN-1, a novel F-box protein that is required in presynaptic neurons for the restriction and/or maturation of synapses in Caenorhabditis elegans PMID: 15208641
4. Identification of FSN-1 as a negative regulator of cep-1-dependent germ cell apoptosis. PMID: 18340346
亞細胞定位：

Cell junction, synapse.
蛋白家族：

FBXO45/Fsn family
組織特異性：

Expressed in GABAergic neuromuscular junctions (NMJs).
數據庫鏈接：

KEGG: cel:CELE_C26E6.5

STRING: 6239.C26E6.5

UniGene: Cel.22711