Recombinant Drosophila melanogaster Ran GTPase-activating protein (RanGap), partial

中文名稱：

黑腹果蠅RanGAP重組蛋白
貨號：

CSB-YP892854DLU
規格：
來源：

Yeast
其他：

中文名稱：

黑腹果蠅RanGAP重組蛋白
貨號：

CSB-EP892854DLU
規格：
來源：

E.coli
其他：

中文名稱：

黑腹果蠅RanGAP重組蛋白
貨號：

CSB-EP892854DLU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

黑腹果蠅RanGAP重組蛋白
貨號：

CSB-BP892854DLU
規格：
來源：

Baculovirus
其他：

中文名稱：

黑腹果蠅RanGAP重組蛋白
貨號：

CSB-MP892854DLU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

RanGAP
Uniprot No.：

Q9VIW3
別名：

RanGAP; Sd; CG9999; Ran GTPase-activating protein; RanGAP; Protein segregation distorter
種屬：

Drosophila melanogaster (Fruit fly)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Trans-acting factor necessary for meiotic distortion. Distortion is only seen in individuals that carry the RanGAP tandem duplication and express a RanGAP truncated protein. Binding of truncated RanGAP product to the Responder(RSP) locus initiates events that lead to sperm dysfunction. During oogenesis, plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components.
基因功能參考文獻：
1. molecular and evolutionary genetics of Segregation Distorter PMID: 22964836
2. Sd, the primary gene responsible for segregation distortion, encodes a mutant RanGAP, a key protein in the Ran signaling pathway required for nuclear transport and other nuclear functions. PMID: 12539236
亞細胞定位：

Cytoplasm. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side.
蛋白家族：

RNA1 family
組織特異性：

Both full-length and truncated protein are expressed in testis (at protein level). Expressed in oocytes and nurse cells (at protein level).
數據庫鏈接：

KEGG: dme:Dmel_CG9999

STRING: 7227.FBpp0080775

UniGene: Dm.3220