Recombinant Drosophila melanogaster Protein lozenge (lz), partial

中文名稱：

黑腹果蠅lz重組蛋白
貨號：

CSB-YP893836DLU
規格：
來源：

Yeast
其他：

中文名稱：

黑腹果蠅lz重組蛋白
貨號：

CSB-EP893836DLU
規格：
來源：

E.coli
其他：

中文名稱：

黑腹果蠅lz重組蛋白
貨號：

CSB-EP893836DLU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

黑腹果蠅lz重組蛋白
貨號：

CSB-BP893836DLU
規格：
來源：

Baculovirus
其他：

中文名稱：

黑腹果蠅lz重組蛋白
貨號：

CSB-MP893836DLU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

lz
Uniprot No.：

Q9W349
別名：

lz; CG1689; Protein lozenge
種屬：

Drosophila melanogaster (Fruit fly)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in prepatterning photoreceptor precursors in the developing eye; in the larval eye disk it defines a subset of cells as an equipotential group that is competent to respond to the sevenless developmental signal and another subset that confer proper photoreceptor identity by positively regulating the homeo box gene Bar. Involved in the aop/pnt dynamic in a Ras-dependent manner to regulate pros expression. Promotes apoptosis in the pupal eye by directly activating aos and klu. Also modulates hid- and rpr-mediated cell death. Regulates amos function in olfactory sensilla development.
基因功能參考文獻：
1. Identification of the Doublesex protein binding sites that activate expression of lozenge in the female genital disc in Drosophila melanogaster has been reported. PMID: 28087460
2. Lz provides key intrinsic information to cells during the second wave of pattern formation in the developing ommatidium. PMID: 24067351
3. mlf participates in a positive feedback loop to fine tune the activity of the RUNX transcription factor Lozenge (LZ) during development of the crystal cells. PMID: 22411814
4. Data demonstrate that Med12 and Med13 but not CycC or Cdk8 are essential for Serpent/Lozenge-induced transactivation in cell culture. PMID: 20368357
5. Results lead to conclude that Ttk69 can either directly or indirectly repress lz gene expression to prevent the premature development of R7 precursor cells in the developing eye of Drosophila. PMID: 20003234
6. Yan regulates Lozenge during eye development PMID: 12111211
7. Lozenge is required to contribute to the repression of cell death mechanisms, creating a permissive environment for the survival of undifferentiated cells in early eye development PMID: 12690448
8. role in crystal cell and plasmatocyte production PMID: 14504400
9. Lz can trigger crystal cell development. PMID: 14657024
10. Lz promotes apoptosis in the eye during pupal development, in part by regulating argos and klumpfuss protein expression. PMID: 15879554
11. Glial cells missing (GCM)/GCM2 play a key role in controlling the size of the crystal cell population by inhibiting lz activation and maintenance PMID: 16176949
12. Required for serpent regulation of u-shaped. PMID: 16730345
13. Srp and Lz do not just specify the crystal cell lineage, but also regulate the later differentiation of these cells. PMID: 17417793
14. Maintenance of the crystal cell hematopoietic lineage choice and the realization of the crystal cell differentiation program rely on cooperation between RUNX factor Lozenge (Lz) and GATA factor Serpent (Srp). PMID: 17418114
15. Results show that the GATA factor Serpent cross-regulates lozenge and u-shaped expression during Drosophila blood cell development. PMID: 17869239
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亞細胞定位：

Nucleus.
組織特異性：

Expressed in the pupal eye during programmed cell death.
數據庫鏈接：

KEGG: dme:Dmel_CG1689

STRING: 7227.FBpp0071255

UniGene: Dm.2929