Recombinant Drosophila melanogaster Integrin beta-nu (betaInt-nu), partial

中文名稱：

黑腹果蠅Itgbn重組蛋白
貨號：

CSB-YP632932DLU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

黑腹果蠅Itgbn重組蛋白
貨號：

CSB-EP632932DLU
規(guī)格：
來源：

E.coli
其他：

中文名稱：

黑腹果蠅Itgbn重組蛋白
貨號：

CSB-EP632932DLU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

黑腹果蠅Itgbn重組蛋白
貨號：

CSB-BP632932DLU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

黑腹果蠅Itgbn重組蛋白
貨號：

CSB-MP632932DLU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Itgbn
Uniprot No.：

Q27591
別名：

Itgbn; beta-nu; betaInt-nu; Itgbetanu; CG1762; Integrin beta-nu
種屬：

Drosophila melanogaster (Fruit fly)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. Can only partially compensate for the loss of beta-PS integrin during primordial midgut cell migration. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/Talin and beta-nu does not. Integrin alpha-PS3/beta-nu is required for effective phagocytosis of apoptotic cells during embryonic development and for the phagocytic elimination of S.aureus by mediating the binding of S.aureus peptidoglycan to larval hemocytes, which probably activates a signaling pathway involving Rac1 and Rac2. Not required for the production of antimicrobial peptides during S.aureus. Upon activation by LanA, integrin alpha-PS3/beta-nu activates Fak in presynapsis to suppress neuromuscular junction (NMJ) growth during larval development and during low crawling activity, but not during higher-crawling conditions. Mediates, together with LanA, glutamate receptor-modulated NMJ growth.
基因功能參考文獻：
1. that integrin alphaPS3/betanu serves as a receptor in the phagocytosis of apoptotic cells and bacteria by Drosophila phagocytes. PMID: 23426364
2. Draper and integrin betanu cooperate in the phagocytic elimination of S. aureus by recognizing distinct cell wall components PMID: 22547074
3. Mutagenesis of the integrin cytoplasmic domain, within the chimera, showed the dominant-negative inhibition was not due to talin sequestration alone and that additional interactions are required. PMID: 16569666
亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Integrin beta chain family
組織特異性：

Expression is confined to the developing midgut endoderm and its precursors during embryogenesis. In the larvae, expression is concentrated in the midgut imaginal disks. Expressed in embryonic and larval hemocytes (at protein level).
數(shù)據(jù)庫鏈接：

KEGG: dme:Dmel_CG1762

STRING: 7227.FBpp0080990

UniGene: Dm.19859