Recombinant Drosophila melanogaster Exostosin-1 (ttv), partial

中文名稱(chēng)：

黑腹果蠅ttv重組蛋白
貨號(hào)：

CSB-YP894651DLU
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱(chēng)：

黑腹果蠅ttv重組蛋白
貨號(hào)：

CSB-EP894651DLU
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱(chēng)：

黑腹果蠅ttv重組蛋白
貨號(hào)：

CSB-EP894651DLU-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱(chēng)：

黑腹果蠅ttv重組蛋白
貨號(hào)：

CSB-BP894651DLU
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱(chēng)：

黑腹果蠅ttv重組蛋白
貨號(hào)：

CSB-MP894651DLU
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

ttv
Uniprot No.：

Q9V730
別名：

ttv; DEXT1; CG10117Exostosin-1; EC 2.4.1.224; EC 2.4.1.225; Protein tout-velu
種屬：

Drosophila melanogaster (Fruit fly)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Botv is the trigger of heparan sulfate chain initiation and polymerization takes place by a complex of ttv and sotv. Plays a central role in the diffusion of morphogens hedgehog (hh), wingless (wg) and decapentaplegic (dpp) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis which are required for movement of hh, dpp and wg morphogens.
基因功能參考文獻(xiàn)：
1. Results suggest that all three Drosophila EXT proteins -- tout-velu, brother of tout-velu, and sister of tout-velu -- are required for the biosynthesis of heparan sulfate proteoglycans, and for the gradient formation of morphogens. PMID: 14998928
2. A novel role for toutvelu (ttv), a regulator of heparan sulfate proteoglycan biosynthesis during germ cell migration. PMID: 17409068
3. The hEXT1 gene was able to rescue a ttv null mutant to adulthood and restore glycosaminoglycan biosynthesis. PMID: 17610078
亞細(xì)胞定位：

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=Localization to the Golgi may be regulated by sau (PubMed:23720043).
蛋白家族：

Glycosyltransferase 47 family
組織特異性：

Ubiquitously expressed in early embryos. Later (in stage 10 embryos), it is expressed at higher level in the nervous system. Ubiquitously expressed in wing imaginal disk.
數(shù)據(jù)庫(kù)鏈接：

KEGG: dme:Dmel_CG10117

STRING: 7227.FBpp0305367

UniGene: Dm.2966