Recombinant Drosophila melanogaster Coiled-coil and C2 domain-containing protein 1-like (l (2)gd1), partial

中文名稱：

黑腹果蠅l(2)gd1重組蛋白
貨號：

CSB-YP895625DLU
規格：
來源：

Yeast
其他：

中文名稱：

黑腹果蠅l(2)gd1重組蛋白
貨號：

CSB-EP895625DLU
規格：
來源：

E.coli
其他：

中文名稱：

黑腹果蠅l(2)gd1重組蛋白
貨號：

CSB-EP895625DLU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

黑腹果蠅l(2)gd1重組蛋白
貨號：

CSB-BP895625DLU
規格：
來源：

Baculovirus
其他：

中文名稱：

黑腹果蠅l(2)gd1重組蛋白
貨號：

CSB-MP895625DLU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

l(2)gd1
Uniprot No.：

Q9VKJ9
別名：

l(2)gd1; lgd; CG4713Coiled-coil and C2 domain-containing protein 1-like; Lethal giant disks protein
種屬：

Drosophila melanogaster (Fruit fly)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Negative regulator of the Notch signaling pathway, acting to restrict the activity of Notch to the dorsoventral (D/V) boundary of the wing imaginal disk. Also causes negative regulation of Notch during vein, eye, and bristle development. Acts by targeting Notch for endosomal degradation or recycling.
基因功能參考文獻：
1. Lgd regulates ESCRT activity by controlling access to the Shrub self-assembly surface. PMID: 28564595
2. lgd cells have a defect that delays degradation of transmembrane proteins, which are residents of the plasma membrane. Furthermore, our results show that the activation of Notch in lgd cells occurs in the lysosome. PMID: 23178945
3. genetic studies indicate that the activation of Notch in ESCRT and lgd mutant cells occurs in a different manner and that the activity of Shrub and other ESCRT components are required for the activation of Notch in lgd mutant cells PMID: 22389409
亞細胞定位：

Cytoplasm.
蛋白家族：

CC2D1 family
組織特異性：

Expressed in wing and eye imaginal disks.
數據庫鏈接：

KEGG: dme:Dmel_CG4713

STRING: 7227.FBpp0297275

UniGene: Dm.4175