Recombinant Drosophila melanogaster Centrosome-associated zinc finger protein CP190 (Cp190), partial

中文名稱：

Recombinant Drosophila melanogaster Centrosome-associated zinc finger protein CP190(Cp190) ,partial
貨號：

CSB-YP637593DLU
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Drosophila melanogaster Centrosome-associated zinc finger protein CP190(Cp190) ,partial
貨號：

CSB-EP637593DLU
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Drosophila melanogaster Centrosome-associated zinc finger protein CP190(Cp190) ,partial
貨號：

CSB-EP637593DLU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Drosophila melanogaster Centrosome-associated zinc finger protein CP190(Cp190) ,partial
貨號：

CSB-BP637593DLU
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Drosophila melanogaster Centrosome-associated zinc finger protein CP190(Cp190) ,partial
貨號：

CSB-MP637593DLU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Cp190
Uniprot No.：

Q24478
別名：

Cp190; E(mod)4-1; CG6384Centrosome-associated zinc finger protein CP190; Protein enhancer of mod(mdg4)4-1; dMAP190
種屬：

Drosophila melanogaster (Fruit fly)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein may directly bind to insulator DNA at sites distinct from those recognized by su(Hw). Required during embryogenesis for axial expansion, an actin/myosin dependent process that distributes the dividing nuclei along the anterior-posterior axis of the syncytial embryo. Does not appear to play a crucial role in organizing centrosomal microtubules during mitosis.
基因功能參考文獻：
1. As binding of CP190 does not enhance luciferase activity in reporter assays. PMID: 24472778
2. we discuss the emerging role of CP190 in tethering genome, specifically in the perspective of insulator function in Drosophila. PMID: 23333867
3. The N-terminal of CP190 containing the BTB/POZ domain and the D-rich region is sufficient to mediate association with the insulator complexes. PMID: 21194420
4. CP190 is an essential protein, as flies homozygous for mutations in the Cp190 gene die at late pupal stages of development. PMID: 14996941
5. CP190 is a component of the gypsy chromatin insulator PMID: 15574329
6. CP190 has distinct nuclear and centrosomal functions, and it provides a crucial link between the centrosome/MT and actin/myosin cytoskeletal systems in early embryos. PMID: 16051175
7. Sumoylation does not affect the ability of CP190 and Mod(mdg4)2.2 to bind chromatin, but instead appears to regulate the nuclear organization of gypsy insulator complexes. PMID: 16628226
8. cis-regulatory elements, domain borders and promoters, the chromatin structure is dependent on CP190. PMID: 19229299
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亞細胞定位：

Nucleus. Cytoplasm, cytoskeleton. Chromosome. Note=Nucleus in interphase. Colocalizes with other elements of the gypsy chromatin insulator complex at multiple sites on polytene chromosomes and at nuclear insulator bodies.
組織特異性：

Expressed in spermatids but not in mature spermatozoa. Localizes within the spermatids to a sheath of microtubules around the nucleus and to microtubules within the tail.
數據庫鏈接：

KEGG: dme:Dmel_CG6384

STRING: 7227.FBpp0082580

UniGene: Dm.2423