Recombinant Bovine T-complex protein 1 subunit alpha (TCP1), partial

中文名稱：

牛TCP1重組蛋白
貨號：

CSB-YP653464BO
規格：
來源：

Yeast
其他：

中文名稱：

牛TCP1重組蛋白
貨號：

CSB-EP653464BO
規格：
來源：

E.coli
其他：

中文名稱：

牛TCP1重組蛋白
貨號：

CSB-EP653464BO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

牛TCP1重組蛋白
貨號：

CSB-BP653464BO
規格：
來源：

Baculovirus
其他：

中文名稱：

牛TCP1重組蛋白
貨號：

CSB-MP653464BO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

TCP1
Uniprot No.：

Q32L40
別名：

TCP1; CCT1; T-complex protein 1 subunit alpha; TCP-1-alpha; CCT-alpha
種屬：

Bos taurus (Bovine)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
基因功能參考文獻：
1. The mammalian TRiC structure was determined at 4.7-A resolution. PMID: 20194787
2. Results indicate that the kinetic mechanism of the allosteric transitions of chaperonin containing t-complex polypeptide 1 (TCP-1) differs considerably from that of GroEL PMID: 12589746
3. unlike GroEL, TRiC does not close its lid upon nucleotide binding, but instead responds to the trigonal-bipyramidal transition state of ATP hydrolysis. PMID: 12732144
4. Data show that chaperonin TRiC binding is specified by two short hydrophobic beta strands in the von Hippel-Lindau protein that, upon folding, become buried within the native structure [TRiC]. PMID: 14636579
5. antagonistic actions of PhLP3 and prefoldin serve to modulate CCT activity and play a key role in establishing a functional cytoskeleton in vivo PMID: 16415341
6. one of the cytosolic chaperonin containing t-complex polypeptide 1 (CCT)/TRiC-specific targets is hydrophobic beta-strands, which are highly prone to aggregation PMID: 16717193
7. Domain movements in TRiC are coordinated through unique interdomain contacts within each subunit and, further, these contacts are absent in prokaryotic chaperonins. PMID: 18536725
8. analysis of the formation of a stable complex between chaperonin-containing TCP-1 (CCT) and Hsc70 PMID: 18660820
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亞細胞定位：

Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
蛋白家族：

TCP-1 chaperonin family
數據庫鏈接：

KEGG: bta:512043

STRING: 9913.ENSBTAP00000003662

UniGene: Bt.4585