Recombinant Bovine Ceroid-lipofuscinosis neuronal protein 5 (CLN5)

中文名稱：

Recombinant Bovine Ceroid-lipofuscinosis neuronal protein 5(CLN5)
貨號：

CSB-YP637368BO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Bovine Ceroid-lipofuscinosis neuronal protein 5(CLN5)
貨號：

CSB-EP637368BO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Bovine Ceroid-lipofuscinosis neuronal protein 5(CLN5)
貨號：

CSB-EP637368BO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Bovine Ceroid-lipofuscinosis neuronal protein 5(CLN5)
貨號：

CSB-BP637368BO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Bovine Ceroid-lipofuscinosis neuronal protein 5(CLN5)
貨號：

CSB-MP637368BO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

CLN5
Uniprot No.：

Q1ZYR0
別名：

CLN5; Ceroid-lipofuscinosis neuronal protein 5; Protein CLN5) [Cleaved into: Ceroid-lipofuscinosis neuronal protein 5; secreted form]
種屬：

Bos taurus (Bovine)
蛋白長度：

Full Length of Mature Protein
表達(dá)區(qū)域：

46-358
氨基酸序列

DPSRR QWPVPYKRFS FRPEPDPYCQ AKYTFCPTGS PIPVMKDDDV IEVFRLQAPV WEFKYGDLLG HLKIMHDAIG FRSTLTEKNY TMEWYELFQL GNCTFPHLRP EMNAPFWCNQ GAACFFEGID DSHWKENGTL VLVATISGGM FNRMAKWVKQ DNETGIYYET WTVQASPERG AERWFESYDC SKFVLRTYEK LAELGADFKK IETNYTRIFL YSGEPTYLGN ETSVFGPTGN KTLALAIKKF YYPFKPHLST KEFLLSLLQI FDAVVIHREF YLFYNFEYWF LPMKYPFIKI TYEEIPLPNR KNRTLSGL
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.
基因功能參考文獻(xiàn)：
1. The candidate genes for bovine Neuronal Ceroid Lipofuscinosis, CLN3, CLN5 and CLN6, have been mapped to facilitate linkage analysis in cattle and sheep. PMID: 16974076
2. The candidate genes for bovine Neuronal Ceroid Lipofuscinosis,CLN3 , CLN5 and CLN6, have been mapped to facilitate linkage analysis in cattle and sheep. PMID: 16974076
相關(guān)疾?。?/div>
Defects in CLN5 are the cause of neuronal ceroid lipofuscinosis (NCL). NCL is characterized by brain atrophy and the accumulation of lysosome derived fluorescent storage bodies in neurons and most other cells. NCL is found in Australian Devon cattle.
亞細(xì)胞定位：

[Ceroid-lipofuscinosis neuronal protein 5, secreted form]: Lysosome.; [Ceroid-lipofuscinosis neuronal protein 5]: Membrane; Single-pass type II membrane protein.
蛋白家族：

CLN5 family
數(shù)據(jù)庫鏈接：

KEGG: bta:529186

STRING: 9913.ENSBTAP00000025093

UniGene: Bt.74270