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STK33 Recombinant Monoclonal Antibody

  • 中文名稱：
    STK33重組抗體
  • 貨號(hào)：
    CSB-RA207790A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA207790A0HU diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    STK33重組單克隆抗體（產(chǎn)品編號(hào)CSB-RA207790A0HU）是針對(duì)絲氨酸/蘇氨酸蛋白激酶33（STK33）研發(fā)的高特異性抗體。STK33是一種參與細(xì)胞周期調(diào)控、DNA損傷修復(fù)及細(xì)胞凋亡的關(guān)鍵信號(hào)分子，其異常表達(dá)與多種腫瘤發(fā)生發(fā)展密切相關(guān)。本抗體通過(guò)重組表達(dá)技術(shù)制備，經(jīng)ELISA和免疫組化（IHC）嚴(yán)格驗(yàn)證，在IHC應(yīng)用中推薦使用1:50-1:200稀釋比例，可清晰定位目標(biāo)蛋白在細(xì)胞質(zhì)或細(xì)胞核中的表達(dá)分布，實(shí)驗(yàn)結(jié)果顯示其具備高親和力與低交叉反應(yīng)性，能夠有效識(shí)別天然及重組STK33蛋白。該產(chǎn)品適用于癌癥發(fā)生機(jī)制研究、細(xì)胞增殖與凋亡相關(guān)信號(hào)通路分析，以及蛋白功能驗(yàn)證等科研領(lǐng)域，為探索STK33在腫瘤微環(huán)境調(diào)控、治療靶點(diǎn)篩選等方向提供可靠工具。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Serine/threonine-protein kinase 33 (EC 2.7.11.1), STK33
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human STK33
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    5H11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME. Not essential for the survival of KRAS-dependent AML cell lines.
  • 基因功能參考文獻(xiàn)：
    1. Dysregulated HIF1alpha/STK33 signaling promotes pancreatic ductal adenocarcinoma (PDAC) growth and progression, this suggests that STK33 is a candidate therapeutic target to improve PDAC treatment. PMID: 29038348
    2. STK33 is a potential oncogene and plays an important role in tumorigenesis of HSCC via regulation of numerous genes. PMID: 27414193
    3. STK33 plays an essential role in hepatocellular proliferation and liver tumorigenesis. STK33 may bind directly to c-Myc and increase its transcriptional activity. PMID: 25398772
    4. Results show that STK33 is a potential oncogene and a promising diagnostic marker for hypopharyngeal squamous cell carcinoma (HSCC). STK33 may promote tumorigenesis and progression of HSCC, and serve as a valuable molecular target for treatment of HSCC. PMID: 25603720
    5. STK33 can promote cell migration and invasion and suppress p53 gene expression in the NL9980 and L9981 large cell lung cancer cell lines. In addition, this protein also promotes epithelial-mesenchymal transition. PMID: 25662617
    6. The STK33-linked SNP rs4929949 is associated with obesity and BMI in two independent cohorts of Swedish and Greek children. PMID: 23967198
    7. STK33 downregulation or dominant mutant overexpression had no effect on KRAS signaling or survival of cancer cells. PMID: 21742770
    8. STK33/Stk33 expression pattern resembles those of some related members of the calcium/calmodulin dependent kinase group PMID: 16176263

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  • 亞細(xì)胞定位：
    Cytoplasm, perinuclear region.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
  • 組織特異性：
    Highly expressed in testis, fetal lung and heart, followed by pituitary gland, kidney, interventricular septum, pancreas, heart, trachea, thyroid gland and uterus. Weak hybridization signals were observed in the following tissues: amygdala, aorta, esophag
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 14568

    OMIM: 607670

    KEGG: hsa:65975

    STRING: 9606.ENSP00000320754

    UniGene: Hs.501833



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