The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA914519(THBS2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
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貨期:
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用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.
基因功能參考文獻:
TWIST2 induces miR-221-3p expression and consequently suppresses its direct target, THBS2, in lymphatic metastasis cervical cancer. PMID: 29242498
THBS2 could be considered as a novel prognostic marker in colorectal cancer. PMID: 27632935
By testing for THBS2 and another marker, CA19-9, researchers identified blood samples from patients with the disease with 98% specificity and 87% sensitivity. PMID: 28739842
the combination of THBS2 and CA19-9 yielded a sensitivity of 87% for pancreatic ductal adenocarcinoma in the phase 2b study. PMID: 28701476
Study found that 2 single nucleotide polymorphisms (rs6422747 and rs6422748) in the THBS2 gene were associated with susceptibility of intervertebral disc degeneration (IDD) but not severity of IDD in a Chinese Han population; results indicated that THBS2 gene polymorphisms might be the risk factors for IDD. PMID: 29480856
TSP-2 enhances the migration of PCa cells by increasing MMP-2 expression through down-regulation of miR-376c expression. PMID: 28122633
we report microRNA-135b (miR-135b), a key regulator of the malignancy, highly expressed in the RC component and promoting MLS cell invasion in vitro and metastasis in vivo through the direct suppression of thrombospondin 2 (THBS2). PMID: 27157622
High THBS2 expression is associated with lung cancer. PMID: 27513329
STMN1,COF1 and PAIRBP1 thus represent proteins associated with proliferative and aggressive tumors of high grades, while TSP2 and POSTN were connected to low grade tumors with better prognosis PMID: 28216224
the tissue levels of THBS2 and LECT-2 may correlate with the stage of atherosclerosis. PMID: 28039493
THBS2 and THBS4 mRNA are overexpressed in gastric cancer in a Southeast Chinese population. PMID: 27160021
The level of THBS2 in differentiating stem cells, influences chondrogenic differentiation potential. PMID: 26235673
THBS2 protein, human is predicting lymph node metastases in OSCC, overall survival and disease-free survival. PMID: 24764155
Study suggests THBS2 is aberrantly expressed in gastric cancer and plays a critical role in cancer progression. PMID: 25262009
No association was observed between the THBS2 3' untranslated region polymorphism and coronary artery disease risk. PMID: 25976449
THBS2 is a salivary biomarker of oral cavity squamous cell carcinoma. PMID: 24708169
Patients whose MPM tissues expressed elevated mRNA levels of BIRC5, DSP, NME2, and THBS2 showed a statistically significant shorter overall survival. PMID: 25771974
Variants within the thrombospondin 2 (THBS2) gene are not associated with Achilles tendinopathy PMID: 23875975
Although no SNPs in THBS2 were associated with lumbar spinal stenosis, two haplotypes were significantly associated with disease progression in the Korean population, whereas another haplotype may play a protective role. PMID: 23807322
TSP-2 is a potentially useful biomarker for assessment of disease severity and prognosis in HFrEF. PMID: 24500070
Estrogen receptor alpha in cancer-associated fibroblasts suppresses prostate cancer invasion via modulation of thrombospondin 2 and matrix metalloproteinase 3. PMID: 24374826
TSP-2 haschondrogenic effects on chondroprogenitor cells via PKCA ERK, p38/MAPK, and Notch signaling pathways. PMID: 23843355
Upregulation of TSP-2 may be a protective mechanism against inflammation and angiogenesis associated with proliferative diabetic retinopathy (PDR). PMID: 23387388
TSP2 is down-regulated at PCa tissues and cell lines, especially at stroma compartment, which could be related to prostate cancer progression. PMID: 23470460
TSP-2 has a protective role against cardiac inflammation, injury, and dysfunction in acute viral myocarditis. PMID: 22308237
Calcific aortic stenosis in associated with upregulation of TSP-2 expression, and inactivation of Akt and NF-kappaB. PMID: 22035575
Endothelial nitric oxide synthase controls the expression of the angiogenesis inhibitor thrombospondin 2 PMID: 21949402
In patients with preeclampsia, we demonstrated 1.7-fold higher tsp-2 compared with control group. PMID: 21682699
Single-nucleotide polymorphism in THBS2 is associated with coronary atherosclerosis. PMID: 20485444
LRP1 and TSP2 stimulate Notch activity by driving trans-endocytosis of the Notch ectodomain into the signal-sending cell PMID: 20472562
the thrombospondin gene 2 T>G single nucleotide polymorphism is decreased only in plaque erosion, with no difference in frequency between other coronary disease and controls PMID: 19631562
Normal human adult corneal keratocytes have mRNA for this protein. PMID: 11943589
inhibits microvascular endothelial cell proliferation by a caspase-independent mechanism PMID: 12058057
All adrenal tissues (control adrenals, nonfunctional adenomas and ACTH-dependent aldosterone-producing adenomas) expressed both TSP1 and TSP2 mRNAs.both TSP1 and TSP2 mRNAs. Correlated closely with the expression of ACTH receptor. PMID: 12358136
Homozygosity for the THBS-2 variant allele is significantly associated with a lower risk of premature myocardial infarction. PMID: 12482844
Decreased thrombospondin-2 expression is associated with human salivary gland carcinomas PMID: 12824879
The 2.6-A-resolution crystal structure of the glycosylated signature domain of human THBS2 was discribed. PMID: 16186819
biophysical analysis of roles of signature domains of thrombospondin-4 and thrombospondin-2 in calcium binding, fine structure, and inter-modular interactions PMID: 16246837
Gene-expression changes in human evolution that involve specific brain regions, including portions of cerebral cortex. PMID: 17182969
TSP1 and TSP2, together with the VLDLR, initiate a nonapoptotic pathway for maintenance of the normal adult vascular endothelium in a quiescent state. PMID: 18032585
TSP-2 was inconsistently expressed in uterine fibroids. PMID: 18089612
regulation of intervertebral disc ECM metabolism by the THBS2-MMP system plays an essential role in the etiology and pathogenesis of LDH. PMID: 18455130
The variant allele of THBS2 is a risk factor for TAA in hypertensive patients, whereas the variant alleles of HSPA8, GPX1, AGT, and TNF are protective against this condition. PMID: 18600213
Mutations targeting intermodular interfaces or calcium binding destabilize the thrombospondin-2 signature domain. PMID: 18682400
TSP-2 was found to be present in some, but not all, annulus cells of the human annulus and the mouse annulus. PMID: 18718009
The expression of metastasis inhibitor genes PTEN and thrombospondin 2 was down-regulated in the supraglottic carcinoma tissue with lymph node metastasis. PMID: 18720079
A significant correlation between microvessel density and the expression of trombospondin-2 (p=0.009) was found. PMID: 18955754
When TSP-2 expression was reduced in tumor- derived pancreatic stellate cells using selective siRNAs, pancreatic cancer cell invasion was inhibited. PMID: 19592030