RTTN Antibody

Name: RTTN Antibody
Brand: CUSABIO
SKU: CSB-PA020581LA01HU

^Discontinued

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RTTN Polyclonal antibody
Uniprot No.：

Q86VV8
基因名：

RTTN
別名：

DKFZP434G145 antibody; Rotatin antibody; Rttn antibody; RTTN_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Rotatin protein (1509-1603AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，RTTN Antibody (CSB-PA020581LA01HU)，的標記方式是Non-conjugated。對于RTTN Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA020581LB01HU	RTTN Antibody, HRP conjugated	ELISA
FITC	CSB-PA020581LC01HU	RTTN Antibody, FITC conjugated
Biotin	CSB-PA020581LD01HU	RTTN Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Involved in the genetic cascade that governs left-right specification. Plays a role in the maintenance of a normal ciliary structure. Required for correct asymmetric expression of NODAL, LEFTY and PITX2.
基因功能參考文獻：
1. RTTN directly interacts with STIL and acts downstream of STIL-mediated centriole assembly, contributing to building full-length centrioles. PMID: 28811500
2. We found a novel homozygous mutation in RTTN associated with microcephalic PD as well as complex brain malformations and congenital dermatitis, thus expanding the phenotypic spectrum of both RTTN-associated diseases and ciliary dysfunction. PMID: 26940245
3. RTTN mutations cause primary microcephaly and primordial dwarfism in humans. PMID: 26608784
4. RTTN mutations therefore link aberrant ciliary function to abnormal development and organization of the cortex in human individuals. PMID: 22939636
5. Study characterizing mouse rotatin gene. PMID: 11900971
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相關疾病：

Microcephaly, short stature, and polymicrogyria with or without seizures (MSSP)
亞細胞定位：

Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with the basal bodies at the primary cilium.
數據庫鏈接：

HGNC: 18654

OMIM: 610436

KEGG: hsa:25914

STRING: 9606.ENSP00000255674

UniGene: Hs.654809