CEP19 Antibody

中文名稱：

CEP19兔多克隆抗體
貨號：

CSB-PA850384LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA850384LA01HU at dilution of 1:100
其他：

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) CEP19 Polyclonal antibody
Uniprot No.：

Q96LK0
基因名：

CEP19
別名：

CEP19 antibody; C3orf34 antibody; HSD5 antibody; Centrosomal protein of 19 kDa antibody; Cep19 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Centrosomal protein of 19 kDa protein (1-163AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，CEP19 Antibody (CSB-PA850384LA01HU)，的標(biāo)記方式是Non-conjugated。對于CEP19 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA850384LB01HU	CEP19 Antibody, HRP conjugated	ELISA
FITC	CSB-PA850384LC01HU	CEP19 Antibody, FITC conjugated
Biotin	CSB-PA850384LD01HU	CEP19 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring to the centrosomes.
基因功能參考文獻(xiàn)：
1. RABL2 binds to CEP19 and the IFT74-IFT81 heterodimer in a mutually exclusive manner. PMID: 28428259
2. CEP19 is recruited to the ciliary base by the centriolar CEP350/FOP complex and then specifically captures GTP-bound RABL2B, which is activated via its intrinsic nucleotide exchange. PMID: 28625565
3. loss of the ciliary protein CEP19 in humans and mice causes morbid obesity. PMID: 24268657
相關(guān)疾病：

Morbid obesity and spermatogenic failure (MOSPGF)
亞細(xì)胞定位：

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, cilium basal body.
蛋白家族：

CEP19 family
數(shù)據(jù)庫鏈接：

HGNC: 28209

OMIM: 615586

KEGG: hsa:84984

STRING: 9606.ENSP00000387209

UniGene: Hs.282800