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DDOST Monoclonal Antibody

  • 中文名稱：
    DDOST Monoclonal Antibody
  • 貨號：
    CSB-MA984809
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of DDOST expression in C2C12 cells using DDOST antibody. Green, isotype control; red, DDOST.
    • Western blotting analysis using DDOST antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with DDOST antibody and HRP-conjugated goat mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) DDOST Monoclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    DDOST; Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Non-Catalytic Subunit; OST48; KIAA0115; WBP1; OST; Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 48 KDa Subunit; Advanced Glycation End-Product Receptor 1; Oligosaccharyl Transferase 48 KDa Subunit; Oligosaccharyltransferase Subunit 48; Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit (Non-Catalytic); Dolichyl-Diphosphooligosaccharide-Protein Glycosyltransferase; Dolichyl-Diphosphooligosaccharide-Protein Glycotransferase; Advanced Glycation Endproduct Receptor 1; Oligosaccharyltransferase 48 KDa Subunit; DDOST 48 KDa Subunit; EC 2.4.1.119; OKSWcl45; AGER1; CDG1R; GATD6
  • 宿主：
    Mouse
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human DDOST protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    20F4
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:100-1:500
    FC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for the assembly of both SST3A- and SS3B-containing OST complexes. Required for efficient N-glycosylation.; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Required for the assembly of both SST3A- and SS3B-containing OST complexes.
  • 基因功能參考文獻：
    1. DDOST and SIRT1 are differently expressed in peripheral blood mononuclear cells from type 1 diabetes patients with and without microvascular complications. Their expression is also influenced by dietary advanced glycation end-products and by statins and angiotensin receptor blockers. PMID: 29027826
    2. the cell-cycle-dependent post-translation modification of TREX1 regulates its interaction with OST. PMID: 28297665
    3. Found a 22 bp deletion and a missense mutation in DDOST. PMID: 22305527
    4. The common SNPs tested in DDOST, PRKCSH and LGALS3 do not seem to be associated with diabetic micro- or macrovascular complications or with type 1 diabetes in Finnish patients. PMID: 20490454
    5. AGER1 provides protection against AGE-induced reactive oxygen species generation via NADPH oxidase and protein kinase C delta. PMID: 19955485

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  • 相關疾病：
    Congenital disorder of glycosylation 1R (CDG1R)
  • 亞細胞定位：
    Endoplasmic reticulum membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    DDOST 48 kDa subunit family
  • 數據庫鏈接：

    HGNC: 2728

    OMIM: 602202

    KEGG: hsa:1650

    STRING: 9606.ENSP00000364188

    UniGene: Hs.523145



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