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Rat Epithelial-Cadherin,E-Cad ELISA Kit

  • 中文名稱:
    大鼠E鈣黏蛋白/上皮鈣黏蛋白(E-Cad)酶聯免疫試劑盒
  • 貨號:
    CSB-E07308r-IS
  • 樣本類型:
    serum, plasma, cell culture supernates, tissue homogenates, cell lysates
  • 檢測范圍:
    0.39ng/ml-25ng/ml
  • 靈敏度:
    0.195ng/ml
  • 規格:
    96T/48T
  • 價格:
    ¥3900/¥2500
  • 促銷:
  • 其他:

產品詳情

  • 別名:
    Cdh1Cadherin-1 ELISA kit; Epithelial cadherin ELISA kit; E-cadherin ELISA kit; Uvomorulin ELISA kit; CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] ELISA kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Rattus norvegicus (Rat)
  • 反應時間:
    3.5h
  • 上樣量:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Cancer
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 儲存條件:
    Store at 2-8°C. Please refer to protocol.
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.; E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
  • 基因功能參考文獻:
    1. Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons PMID: 26658992
    2. astrocyte proliferation can be effectively suppressed by down-regulation of PFKFB3 through control of glycolytic flux, which is downstream of Cdh1 PMID: 26498254
    3. CIP4 overexpression represses E-cadherin expression by promoting beta-catenin translocation to the nucleus. PMID: 26287173
    4. Results suggest a regulatory function of E-cadherin that modulates Nrg1 signaling and promotes Schwann cell myelin formation PMID: 25988855
    5. E-cadherin expression and apoptosis may contribute to the development of Adriamycin nephrotoxicity PMID: 25801296
    6. Zinc can modulate N-cadherin-mediated adhesion. PMID: 25579424
    7. These results suggest that the anaphase-promoting complex-Cdh1 may play an important role in inhibiting axonal growth. PMID: 24634235
    8. results suggest that Cdh1 plays an important role in the regulation of reactive astrocyte proliferation induced by oxygen-glucose deprivation and reperfusion PMID: 23727062
    9. the total amount of E-cadherin expressed in animals subjected to diversion of the fecal stream for 6, 12, and 18 weeks was reduced in segments without a fecal stream. PMID: 23273176
    10. Cadmium disrupts the cadherin/beta-catenin complex in rat kidney cells, this effect leads to partial activation of beta-catenin-mediated gene transcription. PMID: 23080431
    11. E-cadherin is critical for collective sheet migration and is regulated by the chemokine CXCL12 protein during restitution PMID: 22549778
    12. The retaining of E-cadherin in cell-cell adhesion junctions affects the locomotor activity of transformed epithelial cells and plays an important role in their collective migration. PMID: 22288108
    13. E-cadherin can be expressed by a small population of rat undifferentiated spermatogonia in vivo and in vitro. PMID: 21853397
    14. beta-pix forms a complex with cadherin, beta-catenin, and scribble at synapses and enhances localized actin polymerization in rat hippocampal neurons. PMID: 22114281
    15. expression of E-cadherin and alpha-catenin was significantly associated with the ROS and degenerative changes in the seminiferous tubules. PMID: 21399649
    16. Expression of E-cadherin and claudin-4 has a circadian rhythm. The dynamic change in protein levels of E-cadherin and claudin-4 seems to coincide with that in the level of sodium excretion in rats. PMID: 20091493
    17. disappearance of the marginal actin bundle and rearrangements of AJs may change the adhesive function of E-cadherin and play an active role in migratory activity of carcinoma cells PMID: 19956566
    18. Fast dissociation kinetics between individual E-cadherin fragments revealed by flow chamber analysis PMID: 12032067
    19. Cadherin regulates dendritic spine morphogenesis and related synaptic functions, presumably cooperating with cadherin-independent adhesive mechanisms to maintain spine-axon contacts. PMID: 12123610
    20. E-cadherin expression is inversely proportional to tumor size in experimental liver metastases. PMID: 12127823
    21. calcitonin induced reduction in E-cadherin expression may remodel the adherens junctions between epithelial cells PMID: 12237291
    22. different regulation during axonal reorganization in the adult rat CNS PMID: 12387456
    23. In cochlea, E-cad expression is prominent in Hensen cells, Claudius cells, the outer sulcus, the future stria vascularis, and the epithelium (inner layer) of Reissner's membrane. PMID: 12640664
    24. Expression is decreased in iron-loaded hepatocytes PMID: 12651624
    25. Comparison of the expression patterns of E- and P-cadherins during wound healing of the epidermis strongly suggests that these two cadherins play distinct roles in re-epithelialization. PMID: 15771627
    26. It is concluded that CD2AP interacts with E-cadherin and co-localizes with F-actin in the leading edge of migrating cells, and significantly contributes to cell migration in restituting gastric epithelium. PMID: 15910750
    27. Ras signaling causes an upregulation of transcriptional repressors and subsequent downregulation of E-cadherin as a malignant phenotype is propagated PMID: 16153441
    28. Findings demonstrate a stimulatory role for E-cadherin in proliferative regulation, and identify a simple mechanism by which cell-cell contact may trigger or inhibit epithelial cell proliferation in different settings. PMID: 16682529
    29. results suggest that loss of beta-catenin precedes the onset of programmed cell death, loss of E-cadherin and extrusion from the villi. PMID: 16733663
    30. Heparin and enoxaparin can reduce E-cadherin expression in rat pregnancy which might modulate trophoblast invasion. PMID: 16997938
    31. Loss of E-cadherin expression is associated with bladder cancer progression PMID: 17167984
    32. A tight control of E-cadherin expression depending on the differentiation stage of the progenitor cells, is suggested. PMID: 17605082
    33. trefoil factor 3, in contrast to epidermal growth factor, enhanced a collective cell migration ensuring a precise coverage of the re-populated area avoiding gaps PMID: 17762162
    34. Cell adhesion via ECAD has distinct roles in the regulation of intercellular communication between beta-cells within islets, with potential repercussions for insulin secretion. PMID: 17982281
    35. These findings demonstrate a novel role for cell-cell adhesion in polarization, and have implications for wound healing and developmental patterning. PMID: 19258396
    36. These findings reveal a direct role for E-cadherin and for matrix metalloproteinases in causing epithelial-mesenchymal transition downstream of TGF-beta1 in fibrotic disease. PMID: 19590041

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  • 亞細胞定位:
    Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network.
  • 數據庫鏈接:

    KEGG: rno:83502

    STRING: 10116.ENSRNOP00000027346

    UniGene: Rn.1303



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